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Mouse Anti-MSRB3 (AA 33-192) Recombinant Antibody (CBFYM-2670) (CBMAB-M2859-FY)

This product is mouse antibody that recognizes MSRB3. The antibody CBFYM-2670 can be used for immunoassay techniques such as: WB.
See all MSRB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2670
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 33-192

Target

Full Name
METHIONINE SULFOXIDE REDUCTASE B3
Introduction
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
Entrez Gene ID
UniProt ID
Alternative Names
Methionine Sulfoxide Reductase B3; EC 1.8.4.12; Methionine-R-Sulfoxide Reductase B3, Mitochondrial; Methionine-R-Sulfoxide Reductase B3; Deafness, Autosomal Recessive 74; EC 1.8.4.14; DFNB74; MsrB3
Function
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
Biological Process
Protein repair Source: HGNC-UCL
Response to oxidative stress Source: InterPro
Cellular Location
Isoform 1:
Endoplasmic reticulum
Isoform 2:
Mitochondrion
Involvement in disease
Deafness, autosomal recessive, 74 (DFNB74):
A form of non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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