Rabbit Anti-MT-CO2 Recombinant Antibody (A1199) (CBMAB-AP12303LY)

Name: Rabbit Anti-MT-CO2 Recombinant Antibody (A1199)
SKU: CBMAB-AP12303LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

A1199

Application

FC, ICC, IF, IHC, IP, WB

Immunogen

Recombinant protein of human MT-CO2

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Mitochondrially Encoded Cytochrome C Oxidase II

Introduction

MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency and Familial Colorectal Cancer. Among its related pathways are Development EGFR signaling via small GTPases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and cytochrome-c oxidase activity.

Entrez Gene ID

4513

UniProt ID

P00403

Alternative Names

Mitochondrially Encoded Cytochrome C Oxidase II; MTCO2; COII; Cytochrome C Oxidase Polypeptide II; Cytochrome C Oxidase Subunit II; Cytochrome C Oxidase II; EC 1.9.3.1; COXII; COX2;

Function

A11913

Biological Process

ATP synthesis coupled electron transport Source: GO_Central
Cellular respiration Source: ComplexPortal
Lactation Source: Ensembl
Mitochondrial electron transport, cytochrome c to oxygen Source: FlyBase
Positive regulation of ATP biosynthetic process Source: Ensembl
Positive regulation of hydrogen peroxide biosynthetic process Source: Ensembl
Positive regulation of necrotic cell death Source: Ensembl
Response to cold Source: Ensembl

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Mitochondrial complex IV deficiency (MT-C4D):
A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.

Topology

Mitochondrial intermembrane: 1-14
Helical: 15-45
Mitochondrial matrix: 46-59
Helical: 60-87
Mitochondrial intermembrane: 88-227

Skoczylas, S., Płoszaj, T., & Zmysłowska, A. (2023). Can the MT-CO2 gene surprise us with something?–A review of variants considered as pathogenic by identifying conserved sites. Ecological Genetics and Genomics, 100216.

Baty, K., Farrugia, M. E., Hopton, S., Falkous, G., Schaefer, A. M., Stewart, W., ... & Ng, Y. S. (2021). A novel MT-CO2 variant causing cerebellar ataxia and neuropathy: The role of muscle biopsy in diagnosis and defining pathogenicity. Neuromuscular Disorders, 31(11), 1186-1193.

Heidari, M. M., Mirfakhradini, F. S., Tayefi, F., Ghorbani, S., Khatami, M., & Hadadzadeh, M. (2020). Novel point mutations in mitochondrial MT-CO2 gene may be risk factors for coronary artery disease. Applied Biochemistry and Biotechnology, 191(3), 1326-1339.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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