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Mouse Anti-MT1E Recombinant Antibody (CBFYM-2704) (CBMAB-M2894-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2704
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
METALLOTHIONEIN 1E
Introduction
MT1E is a Protein Coding gene. Among its related pathways are Metabolism and Metal ion SLC transporters. An important paralog of this gene is MT1A.
Entrez Gene ID
4493
UniProt ID
P04732
Alternative Names
Metallothionein 1E; Metallothionein-IE; MT-1E; MT-IE; Metallothionein 1E (Functional); Metallothionein-1E; Metallothionein D; MT1; MTD
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Biological Process
Cellular response to cadmium ion Source: UniProtKB
Cellular response to copper ion Source: GO_Central
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB
Cellular Location
Nucleus
Other locations
cytoplasm
More Infomation

Zou, X., Hu, M., Huang, X., Zhou, L., Li, M., Chen, J., ... & Ji, L. (2023). Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population. Diabetes Care, 46(12), 2249-2257.

Ma, M., Qiu, B., Jin, J., Wang, J., Nie, Y., Liang, Y., ... & Teng, C. B. (2021). Establishment of a specific in vivo Cu (Ⅰ) reporting system based on metallothionein screening. Metallomics, 13(7), mfab035.

Zhang, F., Guo, S., Zhong, W., Huang, K., & Liu, Y. (2021). Integrative analysis of metallothioneins identifies MT1H as candidate prognostic biomarker in hepatocellular carcinoma. Frontiers in Molecular Biosciences, 8, 672416.

Liu, Q., Lu, F., & Chen, Z. (2020). Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma. Pathology-Research and Practice, 216(11), 153213.

Bensellam, M., Shi, Y. C., Chan, J. Y., Laybutt, D. R., Chae, H., Abou-Samra, M., ... & Jonas, J. C. (2019). Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans. Diabetologia, 62, 2273-2286.

Masiulionytė, B., Valiulytė, I., Tamašauskas, A., & Skiriutė, D. (2019). Metallothionein genes are highly expressed in malignant astrocytomas and associated with patient survival. Scientific Reports, 9(1), 5406.

Maleckaite, R., Zalimas, A., Bakavicius, A., Jankevicius, F., Jarmalaite, S., & Daniunaite, K. (2019). DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma. Oncology reports, 41(6), 3535-3544.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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