Mouse Anti-MTCP1 (AA 1-68) Recombinant Antibody (CBFYM-2725) (CBMAB-M2918-FY)

This product is mouse antibody that recognizes MTCP1. The antibody CBFYM-2725 can be used for immunoassay techniques such as: ELISA, WB.
See all MTCP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2725

Antibody Isotype

IgG2b, k

Application

ELISA, WB

Basic Information

Immunogen

MTCP1 (AAH02600, AA 1-68 Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-68

Target

Full Name

mature T-cell proliferation 1

Introduction

This gene was identified by involvement in some t translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis.

Entrez Gene ID

4515

UniProt ID

P56278

Alternative Names

Mature T Cell Proliferation 1; Mature T-Cell Proliferation-1 Type B1; Mature T-Cell Proliferation 1; MTCP-1 Type B1; P13MTCP1; Mature T-Cell Proliferation 1 Isoform P13; Protein P13 MTCP-1; P8MTCP1; C6.1B

Function

Enhances the phosphorylation and activation of AKT1 and AKT2.

Biological Process

Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Positive regulation of protein serine/threonine kinase activity Source: UniProtKB

Cellular Location

Protein-containing complex

Involvement in disease

Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

References

Fang, H., Beird, H. C., Wang, S. A., Ibrahim, A. F., Tang, Z., Tang, G., ... & Wang, W. (2023). T-prolymphocytic leukemia: TCL1 or MTCP1 rearrangement is not mandatory to establish diagnosis. Leukemia, 37(9), 1919-1921.

Fang, H., Beird, H., Wang, S., Ibrahim, A., Tang, Z., Tang, G., ... & Wang, W. (2023). Mature T-cell Leukemia Primarily Involving Blood and Bone Marrow without TCL1 or MTCP1 Rearrangement: A Subtype of T-Prolymphocytic Leukemia or a Distinct Entity?.

Molony, P., Smith, A. C., Selvarajah, S., & Sakhdari, A. (2022). MDS/MPN-Unclassifiable with t (X; 17)(q28; q21) and KANSL1-MTCP1/CMC4 Fusion Gene. Cytogenetic and Genome Research, 161(12), 564-568.

Walker, J. S., Hing, Z. A., Sher, S., Cronin, J., Williams, K., Harrington, B., ... & Lapalombella, R. (2021). Rare t (X; 14)(q28; q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. Nature Communications, 12(1), 6338.

Walker, J. S., Hing, Z. A., Sher, S., Cronin, J., Williams, K., Harrington, B., ... & Lapalombella, R. (2021). Evaluating a rare t (X; 14)(q28; q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia. Cancer Research, 81(13_Supplement), 2260-2260.

Li, S. X., Chen, X. J., Jiang, L., Lei, Y. C., Zhang, Y. X., Dai, B., ... & Chen, B. (2020). Identification of at (X; 17)(q28; q21) generating a KANSL1‐MTCP1 gene fusion leading to dysregulated expression of MTCP1 in acute myeloid leukemia. Genes, Chromosomes and Cancer, 59(7), 417-421.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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