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Mouse Anti-MTERF1 (AA 1-100) Recombinant Antibody (CBFYM-2731) (CBMAB-M2924-FY)

This product is mouse antibody that recognizes MTERF1. The antibody CBFYM-2731 can be used for immunoassay techniques such as: ELISA.
See all MTERF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2731
Antibody Isotype
IgG2b, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 1
Introduction
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.
Entrez Gene ID
7978
UniProt ID
Q99551
Alternative Names
Mitochondrial Transcription Termination Factor 1; MTERF; Transcription Termination Factor 1, Mitochondrial; Transcription Termination Factor, Mitochondrial; Mitochondrial Transcription Termination Factor; MTERF1
Function
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.
Biological Process
DNA geometric change Source: UniProtKB
DNA-templated transcription, termination Source: UniProtKB
Regulation of transcription, DNA-templated Source: InterPro
Termination of mitochondrial transcription Source: UniProtKB
Cellular Location
Mitochondrion
PTM
Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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