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Mouse Anti-MTF1 (AA 41-140) Recombinant Antibody (CBFYM-2733) (CBMAB-M2926-FY)

This product is mouse antibody that recognizes MTF1. The antibody CBFYM-2733 can be used for immunoassay techniques such as: ELISA.
See all MTF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2733
Antibody Isotype
IgM, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: GTVYDRTTVL IEQDPGTLED EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP DQIHLTINPG STPMPRNIEG ATLTLQSECP ETKRKEVKRY
Specificity
Human
Antibody Isotype
IgM, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 41-140

Target

Full Name
metal-regulatory transcription factor 1
Introduction
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element.
Entrez Gene ID
UniProt ID
Alternative Names
Metal Regulatory Transcription Factor 1; MRE-Binding Transcription Factor; Transcription Factor MTF-1; Metal-Responsive Transcription Factor 1; MRE-Binding Transcription Factor-1; Zinc Regulatory Factor; MTF-1; ZRF
Function
Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932).

Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932).

Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).
Biological Process
Cartilage homeostasis Source: Ensembl
Cellular response to zinc ion Source: Ensembl
Central nervous system development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to cadmium ion Source: Ensembl
Response to metal ion Source: ProtInc
Response to oxidative stress Source: Ensembl
Transcription, DNA-templated Source: Ensembl
Cellular Location
Cytoplasm
Nucleus
Note: Translocation to the nucleus is induced by metals.

Xu, Y. R., Talukder, M., Li, C. X., Zhang, C., Ge, J., & Li, J. L. (2023). Nanoselenium Alleviates Cadmium-Induced Cerebral Injury via Regulating Cerebral Metal Transporters and Metal-Regulatory Transcription Factor 1. Journal of Agricultural and Food Chemistry.

Wright, G. M., & Black, J. C. (2023). Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells. Cells, 12(6), 953.

Chen, A., Gao, G., Lian, G., Gong, J., Luo, L., Liu, J., ... & Xie, L. (2023). Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension. Cell Cycle, 22(10), 1284-1301.

Lyu, Z., Yang, M., Yang, T., Ma, M., & Yang, Z. (2021). Metal-regulatory transcription factor-1 targeted by miR-148a-3p is implicated in human hepatocellular carcinoma progression. Frontiers in Oncology, 11, 700649.

Talukder, M., Bi, S. S., Jin, H. T., Ge, J., Zhang, C., Lv, M. W., & Li, J. L. (2021). Cadmium induced cerebral toxicity via modulating MTF1-MTs regulatory axis. Environmental Pollution, 285, 117083.

Jia, R., Song, Z., Lin, J., Li, Z., Shan, G., & Huang, C. (2021). Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Nucleic Acids Research, 49(11), 6296-6314.

Valsecchi, V., Laudati, G., Cuomo, O., Sirabella, R., Del Prete, A., Annunziato, L., & Pignataro, G. (2021). The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke. Cell Death & Disease, 12(5), 423.

Jackson, A. C., Liu, J., Vallanat, B., Jones, C., Nelms, M. D., Patlewicz, G., & Corton, J. C. (2020). Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics, 12(9), 1400-1415.

Tavera-Montañez, C., Hainer, S. J., Cangussu, D., Gordon, S. J., Xiao, Y., Reyes-Gutierrez, P., ... & Padilla-Benavides, T. (2019). The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper. The FASEB Journal, 33(12), 14556.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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