Mouse Anti-MTF1 (AA 1-272) Recombinant Antibody (CBFYM-2734) (CBMAB-M2927-FY)

Name: Mouse Anti-MTF1 (AA 1-272) Recombinant Antibody (CBFYM-2734)
SKU: CBMAB-M2927-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2734

Application

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-272

More Infomation

Target

Full Name

metal-regulatory transcription factor 1

Introduction

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element.

Entrez Gene ID

4520

UniProt ID

Q14872

Alternative Names

Metal Regulatory Transcription Factor 1; MRE-Binding Transcription Factor; Transcription Factor MTF-1; Metal-Responsive Transcription Factor 1; MRE-Binding Transcription Factor-1; Zinc Regulatory Factor; MTF-1; ZRF

Function

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932).

Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932).

Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).

Biological Process

Cartilage homeostasis Source: Ensembl
Cellular response to zinc ion Source: Ensembl
Central nervous system development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to cadmium ion Source: Ensembl
Response to metal ion Source: ProtInc
Response to oxidative stress Source: Ensembl
Transcription, DNA-templated Source: Ensembl

Cellular Location

Cytoplasm
Nucleus
Note: Translocation to the nucleus is induced by metals.

Xu, Y. R., Talukder, M., Li, C. X., Zhang, C., Ge, J., & Li, J. L. (2023). Nanoselenium Alleviates Cadmium-Induced Cerebral Injury via Regulating Cerebral Metal Transporters and Metal-Regulatory Transcription Factor 1. Journal of Agricultural and Food Chemistry.

Wright, G. M., & Black, J. C. (2023). Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells. Cells, 12(6), 953.

Chen, A., Gao, G., Lian, G., Gong, J., Luo, L., Liu, J., ... & Xie, L. (2023). Zinc promotes cell proliferation via regulating metal-regulatory transcription factor 1 expression and transcriptional activity in pulmonary arterial hypertension. Cell Cycle, 22(10), 1284-1301.

Lyu, Z., Yang, M., Yang, T., Ma, M., & Yang, Z. (2021). Metal-regulatory transcription factor-1 targeted by miR-148a-3p is implicated in human hepatocellular carcinoma progression. Frontiers in Oncology, 11, 700649.

Talukder, M., Bi, S. S., Jin, H. T., Ge, J., Zhang, C., Lv, M. W., & Li, J. L. (2021). Cadmium induced cerebral toxicity via modulating MTF1-MTs regulatory axis. Environmental Pollution, 285, 117083.

Jia, R., Song, Z., Lin, J., Li, Z., Shan, G., & Huang, C. (2021). Gawky modulates MTF-1-mediated transcription activation and metal discrimination. Nucleic Acids Research, 49(11), 6296-6314.

Valsecchi, V., Laudati, G., Cuomo, O., Sirabella, R., Del Prete, A., Annunziato, L., & Pignataro, G. (2021). The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke. Cell Death & Disease, 12(5), 423.

Jackson, A. C., Liu, J., Vallanat, B., Jones, C., Nelms, M. D., Patlewicz, G., & Corton, J. C. (2020). Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics, 12(9), 1400-1415.

Tavera-Montañez, C., Hainer, S. J., Cangussu, D., Gordon, S. J., Xiao, Y., Reyes-Gutierrez, P., ... & Padilla-Benavides, T. (2019). The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper. The FASEB Journal, 33(12), 14556.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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