Mouse Anti-MTHFS (AA 104-204) Recombinant Antibody (CBFYM-2741) (CBMAB-M2934-FY)

Name: Mouse Anti-MTHFS (AA 104-204) Recombinant Antibody (CBFYM-2741)
SKU: CBMAB-M2934-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2741

Application

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 104-204

More Infomation

Target

Full Name

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

Introduction

The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.

Entrez Gene ID

10588

UniProt ID

P49914

Alternative Names

Methenyltetrahydrofolate Synthetase; 5,10-Methenyltetrahydrofolate Synthetase (5-Formyltetrahydrofolate Cyclo-Ligase); 5-Formyltetrahydrofolate Cyclo-Ligase; Methenyl-THF Synthetase; 5,10-Methenyl-Tetrahydrofolate Synthetase; 5,10-Methenyltetrahydrofolate Synthetase; EC 6.3.3.2; HsT19268

Function

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.

Biological Process

Folic acid catabolic process Source: BHF-UCL
Folic acid-containing compound biosynthetic process Source: GO_Central
Folic acid metabolic process Source: Reactome
Formate metabolic process Source: UniProtKB
Glutamate metabolic process Source: BHF-UCL
Tetrahydrofolate interconversion Source: BHF-UCL
Tetrahydrofolate metabolic process Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination (NEDMEHM):
An autosomal recessive neurodevelopmental disorder with onset at birth or in early infancy, and characterized by microcephaly, short stature, severe global developmental delay, progressive spasticity, and epilepsy. Brain imaging shows delayed myelination, hypomyelination, enlarged ventricles, and cerebellar atrophy.

Vafaee-Shahi, M., Amirkashani, D., Ashrafi, M. R., Tahernia, L., & Riahi, A. (2022). Methenyltetrahydrofolate synthease deficiency (MTHFS deficiency): Novel mutation and brain MRI findings: A case report and glance to other cases. Clinical Neurology and Neurosurgery, 215, 107153.

Sakthivel, D., Lei, Y., Cao, X., & Finnell, R. H. (2020). Homozygous mutation in the MTHFS gene may contribute to the development of cerebral folate deficiency syndrome. Reproductive and Developmental Medicine, 4(02), 72-77.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MTHFS (AA 104-204) Recombinant Antibody (CBFYH-2658) (CAT#: CBMAB-H3702-FY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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