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Mouse Anti-MTHFS (AA 104-204) Recombinant Antibody (CBFYM-2741) (CBMAB-M2934-FY)

This product is mouse antibody that recognizes MTHFS. The antibody CBFYM-2741 can be used for immunoassay techniques such as: WB.
See all MTHFS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2741
Antibody Isotype
IgG1, k
Application
WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 104-204

Target

Full Name
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Introduction
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
10588
UniProt ID
P49914
Alternative Names
Methenyltetrahydrofolate Synthetase; 5,10-Methenyltetrahydrofolate Synthetase (5-Formyltetrahydrofolate Cyclo-Ligase); 5-Formyltetrahydrofolate Cyclo-Ligase; Methenyl-THF Synthetase; 5,10-Methenyl-Tetrahydrofolate Synthetase; 5,10-Methenyltetrahydrofolate Synthetase; EC 6.3.3.2; HsT19268
Function
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Biological Process
Folic acid catabolic process Source: BHF-UCL
Folic acid-containing compound biosynthetic process Source: GO_Central
Folic acid metabolic process Source: Reactome
Formate metabolic process Source: UniProtKB
Glutamate metabolic process Source: BHF-UCL
Tetrahydrofolate interconversion Source: BHF-UCL
Tetrahydrofolate metabolic process Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination (NEDMEHM):
An autosomal recessive neurodevelopmental disorder with onset at birth or in early infancy, and characterized by microcephaly, short stature, severe global developmental delay, progressive spasticity, and epilepsy. Brain imaging shows delayed myelination, hypomyelination, enlarged ventricles, and cerebellar atrophy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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