Mouse Anti-MTIF3 (AA 56-278) Recombinant Antibody (CBFYM-2742) (CBMAB-M2935-FY)

Name: Mouse Anti-MTIF3 (AA 56-278) Recombinant Antibody (CBFYM-2742)
SKU: CBMAB-M2935-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2742

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 56-278 of human MTIF3 (NP_690876) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

4.27 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 56-278

More Infomation

Target

Full Name

MITOCHONDRIAL TRANSLATIONAL INITIATION FACTOR 3

Introduction

This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

Entrez Gene ID

219402

UniProt ID

Q9H2K0

Alternative Names

Mitochondrial Translational Initiation Factor 3; IF-3(Mt); IF3mt; Translation Initiation Factor IF-3, Mitochondrial; IF3(Mt); IF-3Mt

Function

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.

Biological Process

Mitochondrial translational initiation Source: SGD
Ribosome disassembly Source: BHF-UCL

Cellular Location

Mitochondrion

Huang, M., Coral, D., Ardalani, H., Spegel, P., Saadat, A., Claussnitzer, M., ... & Kalamajski, S. (2023). Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function. Elife, 12, e84168.

Lee, S., Park, D., Lim, C., Kim, J. I., & Min, K. T. (2022). mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth. BMC biology, 20, 1-16.

Lee, S., Park, D., Lim, C., Kim, J. I., & Min, K. T. (2021). Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development. bioRxiv, 2021-01.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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