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Mouse Anti-MTMR2 Recombinant Antibody (CBFYM-2748) (CBMAB-M2941-FY)

This product is mouse antibody that recognizes MTMR2. The antibody CBFYM-2748 can be used for immunoassay techniques such as: WB, FC.
See all MTMR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2748
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Full length human recombinant protein of human MTMR2 (NP_057240) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
myotubularin related protein 2
Introduction
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
Entrez Gene ID
8898
UniProt ID
Q13614
Alternative Names
Myotubularin Related Protein 2; Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase; Phosphatidylinositol-3-Phosphate Phosphatase; Phosphatidylinositol-3-Phosphatase; Phosphoinositide-3-Phosphatase; Myotubularin-Related Protein 2; EC 3.1.3.48; EC 3.1.3.95
Function
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594).

Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity).

Stabilizes SBF2/MTMR13 at the membranes (By similarity).

Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity).
Biological Process
Dendritic spine maintenance Source: BHF-UCL
Inositol phosphate dephosphorylation Source: Ensembl
Myelin assembly Source: Ensembl
Negative regulation of endocytosis Source: BHF-UCL
Negative regulation of excitatory postsynaptic potential Source: BHF-UCL
Negative regulation of myelination Source: Ensembl
Negative regulation of receptor catabolic process Source: BHF-UCL
Negative regulation of receptor internalization Source: BHF-UCL
Neuron development Source: Ensembl
Phosphatidylinositol biosynthetic process Source: Reactome
Phosphatidylinositol dephosphorylation Source: UniProtKB
Positive regulation of early endosome to late endosome transport Source: BHF-UCL
Protein dephosphorylation Source: UniProtKB
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB
Cellular Location
Cytoplasm
Endosome
Early endosome membrane
Endosome membrane
Other locations
perinuclear region
axon
Note: Partly associated with membranes (PubMed:12668758, PubMed:15998640, PubMed:21372139). Localizes to vacuoles in hypo-osmotic conditions (By similarity).
Involvement in disease
Charcot-Marie-Tooth disease 4B1 (CMT4B1):
A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
PTM
Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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