Mouse Anti-MTMR9 (AA 450-549) Recombinant Antibody (CBFYM-2751) (CBMAB-M2944-FY)

Name: Mouse Anti-MTMR9 (AA 450-549) Recombinant Antibody (CBFYM-2751)
SKU: CBMAB-M2944-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2751

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: LQQKTMSLWS WVNQPSELSK FTNPLFEANN LVIWPSVAPQ SLPLWEGIFL RWNRSSKYLD EAYEEMVNII EYNKELQAKV NILRRQLAEL ETEDGMQESP

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 450-549

More Infomation

Target

Full Name

myotubularin related protein 9

Introduction

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.

Entrez Gene ID

66036

UniProt ID

Q96QG7

Alternative Names

Myotubularin Related Protein 9; Myotubularin Related Protein 8; C8orf9; MTMR8; Myotubularin-Related Protein 9; LIP-STYX

Function

Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598).

Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598).

Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity).

Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598).

The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970).

Stabilizes MTMR8 protein levels (PubMed:22647598).

Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580).

Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598).

Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598).

Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).

Biological Process

Endocytosis Source: UniProtKB-KW
Negative regulation of autophagy Source: UniProtKB
Phosphatidylinositol dephosphorylation Source: GO_Central
Positive regulation of phosphatase activity Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Cytoplasm
Plasma membrane
ruffle membrane
Other locations
perinuclear region
Note: Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970).

Silva, M. A., Resende, C. M. M., Louro, M. B., Ribeiro, S. A. V., do Carmo Castro Franceschini, S., Velasquez‐Melendez, G., ... & de Novaes, J. F. (2023). Higher atherogenic risk in schoolchildren is associated with MTMR9 rs2293855 gene polymorphism and genetic score. Nutrition Bulletin, 48(4), 559-571.

Silva, M., Resende, C. M. M., Louro, M. B., Ribeiro, S. A. V., Franceschini, S. D. C. C., Velásquez-Meléndez, J. G., ... & de Novaes, J. F. (2021). The Polymorphism rs2293855 MTMR9 Gene and Genetic Score Are Associated With Higher Atherogenic Risk in Brazilian Schoolchildren.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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