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Mouse Anti-MTMR9 (AA 450-549) Recombinant Antibody (CBFYM-2751) (CBMAB-M2944-FY)

This product is mouse antibody that recognizes MTMR9. The antibody CBFYM-2751 can be used for immunoassay techniques such as: ELISA, WB.
See all MTMR9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2751
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: LQQKTMSLWS WVNQPSELSK FTNPLFEANN LVIWPSVAPQ SLPLWEGIFL RWNRSSKYLD EAYEEMVNII EYNKELQAKV NILRRQLAEL ETEDGMQESP
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 450-549

Target

Full Name
myotubularin related protein 9
Introduction
This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
Entrez Gene ID
66036
UniProt ID
Q96QG7
Alternative Names
Myotubularin Related Protein 9; Myotubularin Related Protein 8; C8orf9; MTMR8; Myotubularin-Related Protein 9; LIP-STYX
Function
Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598).

Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598).

Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity).

Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598).

The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970).

Stabilizes MTMR8 protein levels (PubMed:22647598).

Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580).

Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598).

Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598).

Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970).
Biological Process
Endocytosis Source: UniProtKB-KW
Negative regulation of autophagy Source: UniProtKB
Phosphatidylinositol dephosphorylation Source: GO_Central
Positive regulation of phosphatase activity Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of phosphatidylinositol dephosphorylation Source: UniProtKB
Cellular Location
Endoplasmic reticulum
Cytoplasm
Plasma membrane
ruffle membrane
Other locations
perinuclear region
Note: Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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