Mouse Anti-MTO1 Recombinant Antibody (CBFYM-2760) (CBMAB-M2953-FY)

Name: Mouse Anti-MTO1 Recombinant Antibody (CBFYM-2760)
SKU: CBMAB-M2953-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2760

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MITOCHONDRIAL TRNA TRANSLATION OPTIMIZATION 1

Introduction

This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

25821

UniProt ID

Q9Y2Z2

Alternative Names

Mitochondrial TRNA Translation Optimization 1; Mitochondrial Translation Optimization 1 Homolog (S. Cerevisiae); Mitochondrial Translation Optimization 1 Homolog; Protein MTO1 Homolog, Mitochondrial; Homolog Of Yeast Mto1; Mitochondrial MTO1-3

Function

Involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.

Biological Process

Mitochondrial tRNA wobble uridine modification Source: GO_Central
tRNA methylation Source: GO_Central
tRNA wobble uridine modification Source: GO_Central

Cellular Location

Mitochondrion

Involvement in disease

Combined oxidative phosphorylation deficiency 10 (COXPD10):
An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases.

Tomoda, E., Nagao, A., Shirai, Y., Asano, K., Suzuki, T., Battersby, B. J., & Suzuki, T. (2023). Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Nucleic Acids Research, gkad139.

Cheng, X., Shen, C., & Liao, Z. (2022). High Expression of Circular RNA–Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer. Journal of Lower Genital Tract Disease, 26(3), 212.

Chang, C., Zheng, A., Wang, P., & Teng, X. (2022). Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease‐free survival, and higher chemotherapy sensitivity in gastric cancer. Journal of Clinical Laboratory Analysis, 36(6), e23918.

Zhang, Q., He, X., Yao, S., Lin, T., Zhang, L., Chen, D., ... & Guan, M. X. (2021). Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Nucleic Acids Research, 49(8), 4689-4704.

Chen, C., Wang, Q., Aishanjiang, M., Wei, Y., Gao, Z., Chen, Y., ... & Ye, S. (2021). Human blood-derived lymphoblastoid cybrids for assessment of mitochondrial tRNAs deficiency by MTO1 silence.

Luo, Q., Wen, X., Zhou, J., Chen, Y., Lv, Z., Shen, X., & Liu, J. (2021). A novel compound heterozygous mutation of the MTO1 gene associated with complex oxidative phosphorylation deficiency type 10. Clinica Chimica Acta, 523, 172-177.

Kazuhito, T., & Wei, F. Y. (2020). Posttranscriptional modifications in mitochondrial tRNA and its implication in mitochondrial translation and disease. The journal of biochemistry, 168(5), 435-444.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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