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Mouse Anti-MTO1 Recombinant Antibody (CBFYM-2760) (CBMAB-M2953-FY)

This product is mouse antibody that recognizes MTO1. The antibody CBFYM-2760 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MTO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2760
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MITOCHONDRIAL TRNA TRANSLATION OPTIMIZATION 1
Introduction
This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
25821
UniProt ID
Q9Y2Z2
Alternative Names
Mitochondrial TRNA Translation Optimization 1; Mitochondrial Translation Optimization 1 Homolog (S. Cerevisiae); Mitochondrial Translation Optimization 1 Homolog; Protein MTO1 Homolog, Mitochondrial; Homolog Of Yeast Mto1; Mitochondrial MTO1-3
Function
Involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.
Biological Process
Mitochondrial tRNA wobble uridine modification Source: GO_Central
tRNA methylation Source: GO_Central
tRNA wobble uridine modification Source: GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 10 (COXPD10):
An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases.

Tomoda, E., Nagao, A., Shirai, Y., Asano, K., Suzuki, T., Battersby, B. J., & Suzuki, T. (2023). Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Nucleic Acids Research, gkad139.

Cheng, X., Shen, C., & Liao, Z. (2022). High Expression of Circular RNA–Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer. Journal of Lower Genital Tract Disease, 26(3), 212.

Chang, C., Zheng, A., Wang, P., & Teng, X. (2022). Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease‐free survival, and higher chemotherapy sensitivity in gastric cancer. Journal of Clinical Laboratory Analysis, 36(6), e23918.

Zhang, Q., He, X., Yao, S., Lin, T., Zhang, L., Chen, D., ... & Guan, M. X. (2021). Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Nucleic Acids Research, 49(8), 4689-4704.

Chen, C., Wang, Q., Aishanjiang, M., Wei, Y., Gao, Z., Chen, Y., ... & Ye, S. (2021). Human blood-derived lymphoblastoid cybrids for assessment of mitochondrial tRNAs deficiency by MTO1 silence.

Luo, Q., Wen, X., Zhou, J., Chen, Y., Lv, Z., Shen, X., & Liu, J. (2021). A novel compound heterozygous mutation of the MTO1 gene associated with complex oxidative phosphorylation deficiency type 10. Clinica Chimica Acta, 523, 172-177.

Kazuhito, T., & Wei, F. Y. (2020). Posttranscriptional modifications in mitochondrial tRNA and its implication in mitochondrial translation and disease. The journal of biochemistry, 168(5), 435-444.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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