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Mouse Anti-MUC3A Recombinant Antibody (CBFYM-2805) (CBMAB-M2998-FY)

This product is mouse antibody that recognizes MUC3A. The antibody CBFYM-2805 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all MUC3A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2805
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MUCIN 3A, CELL SURFACE ASSOCIATED
Introduction
The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation.
Entrez Gene ID
4584
UniProt ID
Q02505
Alternative Names
Mucin 3A, Cell Surface Associated; MUC-3A; MUC3; Mucin 3A, Intestinal; Mucin 3, Intestinal; Intestinal Mucin-3A; Intestinal Mucin; Mucin-3A
Function
Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
Cellular Location
Isoform 1: Membrane
Isoform 2&3&4&5: Secreted
Topology
Helical: 3227-3247
PTM
Highly O-glycosylated and probably also N-glycosylated.

Merikallio, H., Pincikova, T., Kotortsi, I., Karimi, R., Li, C. X., Forsslund, H., ... & Sköld, M. C. (2023). Mucins 3A and 3B Are Expressed in the Epithelium of Human Large Airway. International Journal of Molecular Sciences, 24(17), 13546.

Sotoudeh, M., Mansouri, V., Shakeri, R., Sharififard, B., Sajadi, N., Haghpanah, V., & Naderi, M. (2023). Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy. Expert Opinion on Therapeutic Targets, 27(12), 1299-1305.

Su, W., Feng, B., Hu, L., Guo, X., & Yu, M. (2022). MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway. BMC cancer, 22(1), 1-14.

Zhao, W., & Xie, Y. (2021). KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A. Pathology-Research and Practice, 217, 153284.

Sun, Y., Sun, X., You, C., Ma, S., Luo, Y., Peng, S., ... & Xie, C. (2021). MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity. International Journal of Biological Sciences, 17(10), 2523.

Luo, Y., Ma, S., Sun, Y., Peng, S., Zeng, Z., Han, L., ... & Xie, C. (2021). MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer. International Journal of Biological Sciences, 17(7), 1671.

Wang, J., Zhou, H., Wang, Y., Huang, H., Yang, J., Gu, W., ... & Yang, J. (2020). Serum mucin 3A as a potential biomarker for extrahepatic cholangiocarcinoma. Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association, 26(3), 129.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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