Mouse Anti-MYB Recombinant Antibody (CBWJC-4219) (CBMAB-C5567WJ)

Name: Mouse Anti-MYB Recombinant Antibody (CBWJC-4219)
SKU: CBMAB-C5567WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-4219

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MYB Proto-Oncogene, Transcription Factor

Introduction

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Entrez Gene ID

4602

UniProt ID

P10242

Alternative Names

MYB Proto-Oncogene, Transcription Factor; V-Myb Avian Myeloblastosis Viral Oncogene Homolog; Proto-Oncogene C-Myb; Transcriptional Activator Myb; Oncogene AMV; C-Myb_CDS; C-Myb; Cmyb; EFG;

Function

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Biological Process

Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Chromatin remodeling Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of hematopoietic progenitor cell differentiation Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of hepatic stellate cell activation Source: Ensembl
Positive regulation of hepatic stellate cell proliferation Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: UniProtKB
Positive regulation of histone H3-K9 methylation Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of testosterone secretion Source: Ensembl
Positive regulation of T-helper cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transforming growth factor beta production Source: Ensembl
Regulation of hematopoietic stem cell differentiation Source: Reactome
Regulation of transcription, DNA-templated Source: GO_Central
Response to hypoxia Source: Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.

Jin, Y., Qi, G., Chen, G., Wang, C., & Fan, X. (2021). Association between B‑Myb proto‑oncogene and the development of malignant tumors. Oncology Letters, 21(2), 1-1.

Cicirò, Y., & Sala, A. (2021). MYB oncoproteins: emerging players and potential therapeutic targets in human cancer. Oncogenesis, 10(2), 19.

Yusenko, M. V., Biyanee, A., Andersson, M. K., Radetzki, S., von Kries, J. P., Stenman, G., & Klempnauer, K. H. (2021). Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner. Cancer Letters, 520, 132-142.

Cao, L., Mitra, P., & Gonda, T. J. (2019). The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein. Scientific Reports, 9(1), 20084.

Werwein, E., Cibis, H., Hess, D., & Klempnauer, K. H. (2019). Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization. Nucleic acids research, 47(1), 103-121.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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