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Rabbit Anti-MYB Recombinant Antibody (D2R4Y) (CBMAB-CP1616-LY)

The product is antibody recognizes MYB. The antibody D2R4Y immunoassay techniques such as: WB,IP.
See all MYB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D2R4Y
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human c-Myb protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MYB Proto-Oncogene, Transcription Factor
Introduction
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Entrez Gene ID
Human4602
Mouse17863
UniProt ID
HumanP10242
MouseP06876
Alternative Names
MYB Proto-Oncogene; Transcription Factor; V-Myb Avian Myeloblastosis Viral Oncogene Homolog; Proto-Oncogene C-Myb; Transcriptional Activator Myb; Oncogene AMV; C-Myb_CDS; C-Myb; Cmyb; EFG;
Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Biological Process
Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Chromatin remodeling Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of hematopoietic progenitor cell differentiation Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of hepatic stellate cell activation Source: Ensembl
Positive regulation of hepatic stellate cell proliferation Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: UniProtKB
Positive regulation of histone H3-K9 methylation Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of testosterone secretion Source: Ensembl
Positive regulation of T-helper cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transforming growth factor beta production Source: Ensembl
Regulation of hematopoietic stem cell differentiation Source: Reactome
Regulation of transcription, DNA-templated Source: GO_Central
Response to hypoxia Source: Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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