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Mouse Anti-MYH8 Antibody (N3.36) (CBMAB-0087-YC)

Provided herein are mouse monoclonal antibodies against Human MYH8. The antibody clone N3.36 can be used for immunoassay techniques, such as ELISA, IF, IHC, WB and IP.
See all MYH8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Rodent
Clone
N3.36
Antibody Isotype
IgM
Application
ELISA, IF, IHC, WB, IP

Basic Information

Immunogen
Partially purified myosin (pyrophosphate extracted) from human neonatal (5 days old) skeletal muscle
Specificity
Human, Cattle, Rodent
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYOSIN HEAVY CHAIN 8
Introduction
This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene is predominantly expressed in fetal skeletal muscle. A mutation in this gene results in trismus-pseudocamptodactyly syndrome.
Entrez Gene ID
Human4626
Cattle281339
UniProt ID
HumanP13535
CattleA0A3Q1LVZ9
Alternative Names
DA7; MyHC-pn; gtMHC-F; MyHC-peri
Function
Muscle contraction.
Biological Process
ATP metabolic process Source: BHF-UCL
Muscle contraction Source: UniProtKB
Muscle filament sliding Source: BHF-UCL
Skeletal muscle contraction Source: BHF-UCL
Cellular Location
Myofibril
Note: Thick filaments of the myofibrils.
Involvement in disease
Carney complex variant (CACOV):
Carney complex is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Familial cardiac myxomas are associated with spotty pigmentation of the skin and other phenotypes, including primary pigmented nodular adrenocortical dysplasia, extracardiac (frequently cutaneous) myxomas, schwannomas, and pituitary, thyroid, testicular, bone, ovarian, and breast tumors. Cardiac myxomas do not develop in all patients with the Carney complex, but affected patients have at least two features of the complex or one feature and a clinically significant family history.
Arthrogryposis, distal, 7 (DA7):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA7 is characterized by an inability to open the mouth fully (trismus) and pseudocamptodactyly in which wrist dorsiflexion, but not volarflexion, produces involuntary flexion contracture of distal and proximal interphalangeal joints. Additional features include shortened hamstring muscles and short stature.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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