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Rabbit Anti-MYL12A (N-terminus) Recombinant Antibody (CBFYM-2949) (CBMAB-M3144-FY)

This product is rabbit antibody that recognizes MYL12A. The antibody CBFYM-2949 can be used for immunoassay techniques such as: WB, ICC, FC.
See all MYL12A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYM-2949
Antibody Isotype
IgG
Application
WB, ICC, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
MYOSIN LIGHT CHAIN 12A
Introduction
This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor /Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.
Entrez Gene ID
10627
UniProt ID
P19105
Alternative Names
Myosin Light Chain 12A; Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD); Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric; Myosin Regulatory Light Chain 2, Nonsarcomeric; Myosin Regulatory Light Chain MRLC3; Epididymis Secretory Protein Li 24; Myosin Regulatory Light Chain 3; Myosin RLC; HEL-S-24
Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
Biological Process
Platelet aggregation Source: UniProtKB
Cellular Location
Cytoskeleton
myosin II complex
Cytosol
extracellular exosome
Other locations
cytoplasm
PTM
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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