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Mouse Anti-MYO5B (AA 940-1051) Recombinant Antibody (CBFYM-2991) (CBMAB-M3186-FY)

This product is mouse antibody that recognizes MYO5B. The antibody CBFYM-2991 can be used for immunoassay techniques such as: WB.
See all MYO5B antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYM-2991
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Rat Myr6 aa. 940-1051
Specificity
Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 940-1051

Target

Full Name
MYOSIN VB
Introduction
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease.
Entrez Gene ID
25132
UniProt ID
P70569
Alternative Names
Myosin VB; Unconventional Myosin-Vb; MYO5B Variant Protein; Myosin-Vb; KIAA1119
Function
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
Biological Process
Actin filament organization Source: GO_Central
Endosomal transport Source: UniProtKB
Protein transport Source: UniProtKB-KW
Renal water homeostasis Source: Reactome
Vesicle-mediated transport Source: UniProtKB
Vesicle transport along actin filament Source: GO_Central
Cellular Location
Cytoplasm
Involvement in disease
Diarrhea 2, with microvillus atrophy (DIAR2):
A disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.

Vij, M., & Shah, V. (2022). Compound heterozygous myosin 5B (Myo5b) mutation with early onset progressive cholestasis and no intestinal failure. Fetal and Pediatric Pathology, 41(5), 811-817.

Bowman, D. M., Kaji, I., & Goldenring, J. R. (2022). Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular Level. Cellular and Molecular Gastroenterology and Hepatology, 14(3), 553-565.

Wang, L., Qiu, Y. L., Xu, H. M., Zhu, J., Li, S. J., OuYang, W. X., ... & Wang, J. S. (2022). MYO5B‐associated diseases: Novel liver‐related variants and genotype‐phenotype correlation. Liver International, 42(2), 402-411.

Li, Q., Zhou, Z., Sun, Y., Sun, C., Klappe, K., & van IJzendoorn, S. C. (2022). A functional relationship between UNC45A and MYO5B connects two rare diseases with shared enteropathy. Cellular and molecular gastroenterology and hepatology, 14(2), 295-310.

Kaji, I., Roland, J. T., Rathan-Kumar, S., Engevik, A. C., Burman, A., Goldstein, A. E., ... & Goldenring, J. R. (2021). Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance. JCI insight, 6(16).

Aldrian, D., Vogel, G. F., Frey, T. K., Ayyıldız Civan, H., Aksu, A. Ü., Avitzur, Y., ... & Janecke, A. R. (2021). Congenital diarrhea and cholestatic liver disease: phenotypic spectrum associated with MYO5B mutations. Journal of Clinical Medicine, 10(3), 481.

Overeem, A. W., Li, Q., Qiu, Y. L., Cartón‐García, F., Leng, C., Klappe, K., ... & van Ijzendoorn, S. C. (2020). A molecular mechanism underlying genotype‐specific intrahepatic cholestasis resulting from MYO5B mutations. Hepatology, 72(1), 213-229.

Tomić, T. T., Olausson, J., Rehammar, A., Deland, L., Muth, A., Ejeskär, K., ... & Abel, F. (2020). MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression. PLoS genetics, 16(6), e1008803.

Leng, C., Overeem, A. W., Cartón-Garcia, F., Li, Q., Klappe, K., Kuipers, J., ... & van IJzendoorn, S. C. (2019). Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation. PLoS biology, 17(11), e3000531.

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For research use only. Not intended for any clinical use.

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