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Mouse Anti-MYO9A (AA 719-828) Recombinant Antibody (CBFYM-2994) (CBMAB-M3189-FY)

This product is mouse antibody that recognizes MYO9A. The antibody CBFYM-2994 can be used for immunoassay techniques such as: ELISA, WB.
See all MYO9A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2994
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: GKRNIHRKTG HDDTAPCAIL KSMDSFSFLQ HPVHQRSLEI LQRCKEEKYS ITRKNPRTPL SDLQGMNALN EKNQHDTFDI AWNGRTGIRQ SRLSSGTSLL DKDGIFANST
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 719-828

Target

Full Name
myosin IXA
Introduction
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9. Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome.
Entrez Gene ID
4649
UniProt ID
B2RTY4
Alternative Names
Myosin IXA; Unconventional Myosin-9a; Unconventional Myosin-IXa; Myosin-IXa; MYR7
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).
Biological Process
Cell junction assembly Source: UniProtKB
Establishment of epithelial cell apical/basal polarity Source: UniProtKB
Intracellular signal transduction Source: InterPro
Positive regulation of GTPase activity Source: InterPro
Regulation of neuron projection arborization Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Visual perception Source: ProtInc
Cellular Location
Cytoplasm
Other locations
Membrane
synapse
growth cone
Note: Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (By similarity).
Involvement in disease
Myasthenic syndrome, congenital, 24, presynaptic (CMS24):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS24 inheritance is autosomal recessive.
Topology
Helical: 175-195
PTM
Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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