Mouse Anti-MYO9A (AA 719-828) Recombinant Antibody (CBFYM-2994) (CBMAB-M3189-FY)

Name: Mouse Anti-MYO9A (AA 719-828) Recombinant Antibody (CBFYM-2994)
SKU: CBMAB-M3189-FY
Rating: 5 (1 reviews)

See all MYO9A antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2994

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: GKRNIHRKTG HDDTAPCAIL KSMDSFSFLQ HPVHQRSLEI LQRCKEEKYS ITRKNPRTPL SDLQGMNALN EKNQHDTFDI AWNGRTGIRQ SRLSSGTSLL DKDGIFANST

Specificity

Human

Antibody Isotype

IgG2a, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 719-828

More Infomation

Target

Full Name

myosin IXA

Introduction

This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9. Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome.

Entrez Gene ID

4649

UniProt ID

B2RTY4

Alternative Names

Myosin IXA; Unconventional Myosin-9a; Unconventional Myosin-IXa; Myosin-IXa; MYR7

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).

Biological Process

Cell junction assembly Source: UniProtKB
Establishment of epithelial cell apical/basal polarity Source: UniProtKB
Intracellular signal transduction Source: InterPro
Positive regulation of GTPase activity Source: InterPro
Regulation of neuron projection arborization Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Visual perception Source: ProtInc

Cellular Location

Cytoplasm
Other locations
Membrane
synapse
growth cone
Note: Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane. Localized at the neuromuscular junction (By similarity).

Involvement in disease

Myasthenic syndrome, congenital, 24, presynaptic (CMS24):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS24 inheritance is autosomal recessive.

Topology

Helical: 175-195

PTM

Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.

Guo, J., Chen, L. W., Huang, Z. Q., Guo, J. S., Li, H., Shan, Y., ... & Shan, Z. X. (2022). Suppression of the inhibitory effect of circ_0036176-translated Myo9a-208 on cardiac fibroblast proliferation by miR-218-5p. Journal of Cardiovascular Translational Research, 15(3), 548-559.

Li, Q., Gulati, A., Lemaire, M., Nottoli, T., Bale, A., & Tufro, A. (2021). Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis. Kidney international, 99(5), 1102-1117.

Schlöndorff, J. S. (2021). My, oh, MYO9A! Just how complex can regulation of the podocyte actin cytoskeleton get?. Kidney International, 99(5), 1065-1067.

Hanley, P. J., Vollmer, V., & Bähler, M. (2020). Class IX myosins: motorized RhoGAP signaling molecules. Myosins: A Superfamily of Molecular Motors, 381-389.

O’Connor, E., Cairns, G., Spendiff, S., Burns, D., Hettwer, S., Mäder, A., ... & Lochmüller, H. (2019). Modulation of agrin and RhoA pathways ameliorates movement defects and synapse morphology in MYO9A-depleted zebrafish. Cells, 8(8), 848.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MYO9A (AA 719-828) Recombinant Antibody (CBFYM-2994)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-MYO9A Recombinant Antibody (4C11) (CAT#: CBMAB-A5747-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry