Mouse Anti-MYOZ2 (AA 1-264) Recombinant Antibody (CBFYM-3019) (CBMAB-M3214-FY)

Name: Mouse Anti-MYOZ2 (AA 1-264) Recombinant Antibody (CBFYM-3019)
SKU: CBMAB-M3214-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-3019

Application

ELISA, WB

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-264

More Infomation

Target

Full Name

myozenin 2

Introduction

The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder.

Entrez Gene ID

51778

UniProt ID

Q9NPC6

Alternative Names

Myozenin 2; FATZ-Related Protein 2; C4orf5; Calcineurin-Binding Protein Calsarcin-1; Chromosome 4 Open Reading Frame 5; Muscle-Specific Protein

Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Biological Process

Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL

Cellular Location

Z line
Note: Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.

Involvement in disease

Cardiomyopathy, familial hypertrophic 16 (CMH16):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Wei, D., Zhang, J., Raza, S. H. A., Song, Y., Jiang, C., Song, X., ... & Quan, G. (2022). Interaction of MyoD and MyoG with Myoz2 gene in bovine myoblast differentiation. Research in Veterinary Science, 152, 569-578.

Yang, Y., Wu, Y., Ji, M., Rong, X., Zhang, Y., Yang, S., ... & Cao, G. (2022). The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes. BMC genomics, 23(1), 700.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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