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Mouse Anti-MYOZ2 (AA 1-264) Recombinant Antibody (CBFYM-3019) (CBMAB-M3214-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3019
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-264

Target

Full Name
myozenin 2
Introduction
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder.
Entrez Gene ID
51778
UniProt ID
Q9NPC6
Alternative Names
Myozenin 2; FATZ-Related Protein 2; C4orf5; Calcineurin-Binding Protein Calsarcin-1; Chromosome 4 Open Reading Frame 5; Muscle-Specific Protein
Function
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
Biological Process
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Sarcomere organization Source: BHF-UCL
Skeletal muscle fiber adaptation Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Cellular Location
Z line
Note: Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.
Involvement in disease
Cardiomyopathy, familial hypertrophic 16 (CMH16):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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