Mouse Anti-MYT1 (AA 586-685) Recombinant Antibody (CBFYM-3022) (CBMAB-M3217-FY)

Name: Mouse Anti-MYT1 (AA 586-685) Recombinant Antibody (CBFYM-3022)
SKU: CBMAB-M3217-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-3022

Antibody Isotype

IgG2a, λ

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: DYASFDAQVF GKRMLAPKIQ TSETSPKAFQ CFDYSQDAEA AHMAATAILN LSTRCWEMPE NLSTKPQDLP SKSVDIEVDE NGTLDLSMHK HRKRENAFPS

Specificity

Human

Antibody Isotype

IgG2a, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 586-685

Target

Full Name

myelin transcription factor 1

Introduction

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

Entrez Gene ID

4661

UniProt ID

Q01538

Alternative Names

Myelin Transcription Factor 1; Neural Zinc Finger Transcription Factor 2; Myelin Transcription Factor I; PLPB1; MTF1; MYTI; Proteolipid Protein Binding Protein; Proteolipid Protein-Binding Protein

Function

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.

Biological Process

Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Xing, L., Chai, R., Wang, J., Lin, J., Li, H., Wang, Y., ... & Chen, G. (2022). Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. Journal of Biological Chemistry, 298(10).

Ding, H., Li, Y., Zhang, Y., Meng, H., Wang, K., Sun, Q., ... & He, F. (2021). Bioinformatics analysis of myelin transcription factor 1. Technology and Health Care, 29(S1), 441-453.

Ghanbarirad, M., Hashemi, M., Saberi, S. M., & Majd, A. (2021). Dysregulation of Myt1 expression acts as a potential peripheral biomarker for major depressive disorder and bipolar disorder. Journal of Neurogenetics, 35(4), 381-386.

Chen, K., Cai, Y., Cheng, C., Zhang, J., Lv, F., Xu, G., ... & Wu, Z. (2020). MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex. Oncogene, 39(21), 4212-4226.

Lee, J., Taylor, C. A., Barnes, K. M., Shen, A., Stewart, E. V., Chen, A., ... & Shen, K. (2019). A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Elife, 8, e46703.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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