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Mouse Anti-MYT1L (AA 301-410) Recombinant Antibody (CBFYM-3023) (CBMAB-M3218-FY)

This product is mouse antibody that recognizes MYT1L. The antibody CBFYM-3023 can be used for immunoassay techniques such as: ELISA, WB.
See all MYT1L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3023
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA KEDGCHERDD
Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 301-410

Target

Full Name
myelin transcription factor 1-like
Introduction
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants.
Entrez Gene ID
23040
UniProt ID
Q9UL68
Alternative Names
Myelin Transcription Factor 1 Like; Neural Zinc Finger Transcription Factor 1; MyT1-L; Myelin Transcription Factor 1-Like Protein; KIAA1106; ZC2H2C2
Function
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nervous system development Source: UniProtKB
Neuron development Source: UniProtKB
Neuron differentiation Source: UniProtKB
Neuron fate commitment Source: UniProtKB
Neuron fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
Other locations
Chromosome
Note: Preferentially binds to DNA binding sites that are in an open chromatin configuration.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 39 (MRD39):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.

Fahim, I., Ishaque, A., Ramzan, F., Shamsuddin, S. A. B. A., Ali, A., Salim, A., & Khan, I. (2023). Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into Oligodendrocytes. Current issues in molecular biology, 45(5), 4100-4123.

Chen, J., Fuhler, N. A., Noguchi, K. K., & Dougherty, J. D. (2023). MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain. Genome research, 33(4), 541-556.

Xing, L., Chai, R., Wang, J., Lin, J., Li, H., Wang, Y., ... & Chen, G. (2022). Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. Journal of Biological Chemistry, 298(10).

Kim, S., Oh, H., Choi, S. H., Yoo, Y. E., Noh, Y. W., Cho, Y., ... & Kim, E. (2022). Postnatal age-differential ASD-like transcriptomic, synaptic, and behavioral deficits in Myt1l-mutant mice. Cell Reports, 40(12).

Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., ... & Dougherty, J. D. (2021). A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation. Neuron, 109(23), 3775-3792.

He, X., Liu, Z., Pang, Y., Xu, W., Zhao, L., & Li, H. (2020). Downregulation of transcription factor TCTP elevates microRNA-200a expression to restrain Myt1L expression, thereby improving neurobehavior and oxidative stress injury in cerebral palsy rats. Cell Cycle, 19(8), 855-869.

Wang, B., Li, D., Yao, Y., Heyns, M., Kovalchuk, A., Ilnytskyy, Y., ... & Kovalchuk, I. (2019). The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. Cell Cycle, 18(21), 2876-2892.

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For research use only. Not intended for any clinical use.

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