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Human Anti-MZB1 Recombinant Antibody (CBFYM-0400) (CBMAB-M0504-FY)

This product is human antibody that recognizes MZB1. The antibody CBFYM-0400 can be used for immunoassay techniques such as: FC.
See all MZB1 antibodies

Summary

Host Animal
Human
Specificity
Rat
Clone
CBFYM-0400
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Marginal Zone B And B1 Cell Specific Protein
Introduction
MZB1 is a Protein Coding gene.
Entrez Gene ID
291675
UniProt ID
Q561R0
Alternative Names
Marginal Zone B And B1 Cell Specific Protein; Plasma Cell-Induced Resident Endoplasmic Reticulum Protein; Mesenteric Oestrogen-Dependent Adipose Gene- 7; Mesenteric Estrogen-Dependent Adipose 7; Plasma Cell-Induced Resident ER Protein; Proapoptotic Caspase Adaptor Protein; Proapoptotic Caspase Adapter Protein; Plasma Cell-Induced ER Protein 1; MEDA-7
Function
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).

Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion and integrin activation.

Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
Biological Process
Apoptotic process Source: UniProtKB-KW
Integrin activation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of immunoglobulin production Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: UniProtKB
Cellular Location
Isoform 1:
Endoplasmic reticulum
Endoplasmic reticulum lumen
Secreted
Isoform 2:
Cytoplasm
Note: Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
PTM
Forms an interchain disulfide bond with IgM monomers.

Tang, Y., Feng, X., Lu, Q., Cui, C., Yu, M., Wen, Z., ... & Wang, J. Y. (2023). MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation. Mucosal Immunology.

Sunnetci‐Akkoyunlu, D., Guzeldemir‐Akcakanat, E., Alkan, B., Gurel, B., Balta‐Uysal, V. M., Akgun, E., ... & Olgac, V. (2023). Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis. Journal of Periodontology.

Zhang, L., Wang, Y. N., Ju, J. M., Shabanova, A., Li, Y., Fang, R. N., ... & Yang, B. F. (2021). Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation. Acta Pharmacologica Sinica, 42(5), 691-700.

Zhu, X., Liu, D., Wang, Y., & Dong, M. (2020). Salidroside suppresses nonsmall cell lung cancer cells proliferation and migration via microRNA-103-3p/Mzb1. Anti-Cancer Drugs, 31(7), 663-671.

Chanukuppa, V., Paul, D., Taunk, K., Chatterjee, T., Sharma, S., Shirolkar, A., ... & Rapole, S. (2020). Proteomics and functional study reveal marginal zone B and B1 cell specific protein as a candidate marker of multiple myeloma. International Journal of Oncology, 57(1), 325-337.

Watanabe, M., Shibata, M., Inaishi, T., Ichikawa, T., Soeda, I., Miyajima, N., ... & Nagino, M. (2020). MZB1 expression indicates poor prognosis in estrogen receptor‑positive breast cancer. Oncology letters, 20(5), 1-1.

Suzuki, K., Vogelzang, A., & Fagarasan, S. (2019). MZB1 folding and unfolding the role of IgA. Proceedings of the National Academy of Sciences, 116(27), 13163-13165.

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., ... & Wang, J. Y. (2019). MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation. Proceedings of the National Academy of Sciences, 116(27), 13480-13489.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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