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MZB1

MZB1 (Marginal Zone B And B1 Cell Specific Protein) is a protein coding gene.

Full Name

Marginal Zone B And B1 Cell Specific Protein

Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity).

Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion and integrin activation.

Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

Biological Process

Apoptotic process Source: UniProtKB-KW
Integrin activation Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of immunoglobulin production Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of cell population proliferation Source: UniProtKB
Regulation of insulin receptor signaling pathway Source: UniProtKB

Cellular Location

Isoform 1:
Endoplasmic reticulum
Endoplasmic reticulum lumen
Secreted
Isoform 2:
Cytoplasm
Note: Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).

PTM

Forms an interchain disulfide bond with IgM monomers.

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Anti-MZB1 antibodies

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Rabbit Anti-MZB1 Recombinant Antibody (055) (CBMAB-P0521-YC)

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Target: MZB1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 055

Application*: E

Rabbit Anti-MZB1 Recombinant Antibody (022) (CBMAB-P0520-YC)

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Target: MZB1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 022

Application*: P

Human Anti-MZB1 Recombinant Antibody (CBFYM-0400) (CBMAB-M0504-FY)

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Target: MZB1

Host: Human

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBFYM-0400

Application*: F

Human Recombinant MZB1 protein, His Tag (V2LY-0526-LY5682)

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Target: MZB1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-185

Tag: His Tag

Human Recombinant MZB1 protein, hFc Tag (V2LY-0526-LY5681)

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Target: MZB1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-185

Tag: hFc Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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