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Mouse Anti-MZF1 Recombinant Antibody (1F7) (CBMAB-A5762-LY)

The product is antibody recognizes MZF1. The antibody 1F7 immunoassay techniques such as: WB, ELISA.
See all MZF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F7
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MZF1 (NP_003413, 419 a.a. ~ 518 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MZF1
Entrez Gene ID
7593
UniProt ID
P28698
Alternative Names
MZF-1; MZF1B; ZNF42; ZSCAN6; Zfp98
Function
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleus

Qu, Z., Zhang, B., Kong, L., Zhang, Y., Zhao, Y., Gong, Y., ... & Yan, L. (2024). Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway. Journal of Leukocyte Biology, qiae011.

Li, B., Li, S., Shi, X., Zhang, Y., Xin, Z., Yang, Y., ... & Wu, H. (2023). MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor). Genes & Diseases, 10(5), 1775.

Shima, A., Matsuoka, H., Yamaoka, A., & Michihara, A. (2021). Transcription of CLDND1 in human brain endothelial cells is regulated by the myeloid zinc finger 1. Clinical and Experimental Pharmacology and Physiology, 48(2), 260-269.

Brix, D. M., Bundgaard Clemmensen, K. K., & Kallunki, T. (2020). Zinc finger transcription factor MZF1—a specific regulator of cancer invasion. Cells, 9(1), 223.

Yue, C. H., Liu, J. Y., Chi, C. S., Hu, C. W., Tan, K. T., Huang, F. M., ... & Lee, C. J. (2019). Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells. Anticancer research, 39(8), 4149-4164.

Lin, S., Wang, X., Pan, Y., Tian, R., Lin, B., Jiang, G., ... & Huang, J. (2019). Transcription factor myeloid zinc-finger 1 suppresses human gastric carcinogenesis by interacting with metallothionein 2A. Clinical Cancer Research, 25(3), 1050-1062.

Kuo, M. C., Kuo, P. C., & Mi, Z. (2019). Myeloid zinc finger-1 regulates expression of cancer-associated fibroblast and cancer stemness profiles in breast cancer. Surgery, 166(4), 515-523.

Davis, S. M., Collier, L. A., Foran, E. A., Leonardo, C. C., Ajmo, C. T., & Pennypacker, K. R. (2019). Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke. Metabolic brain disease, 34, 631-640.

Brix, D. M., Tvingsholm, S. A., Hansen, M. B., Clemmensen, K. B., Ohman, T., Siino, V., ... & Kallunki, T. (2019). Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion. Oncogene, 38(17), 3170-3184.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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