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Mouse Anti-NACC2 Antibody (3E5) (CBMAB-0701-YC)

Provided herein are mouse monoclonal antibodies against Human NACC2. The antibody clone 3E5 can be used for immunoassay techniques, such as IP, WB and MA.
See all NACC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E5
Antibody Isotype
IgG1
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NACC2
Introduction
NACC2 (nucleus accumbens-associated protein 2) is a protein that has protein homodimerization activity and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Diseases associated with NACC2 include interstitial myocarditis and Fiedler's myocarditis. An important paralog of this gene is NACC1.
Entrez Gene ID
138151
UniProt ID
Q96BF6
Alternative Names
BEND9; BTBD14A; BTBD31; MGC23427
Function
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.
Biological Process
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Protein-containing complex localization Source: BHF-UCL
Protein homooligomerization Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Note: Predominantly associated with chromatin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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