Mouse Anti-NACC2 Antibody (3E5) (CBMAB-0701-YC)

Name: Mouse Anti-NACC2 Antibody (3E5)
SKU: CBMAB-0701-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E5

Application

IP, WB, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NACC2

Introduction

NACC2 (nucleus accumbens-associated protein 2) is a protein that has protein homodimerization activity and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Diseases associated with NACC2 include interstitial myocarditis and Fiedler's myocarditis. An important paralog of this gene is NACC1.

Entrez Gene ID

138151

UniProt ID

Q96BF6

Alternative Names

BEND9; BTBD14A; BTBD31; MGC23427

Function

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

Biological Process

Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
Protein-containing complex localization Source: BHF-UCL
Protein homooligomerization Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus
Note: Predominantly associated with chromatin.

Wang, X. Z., Chen, L., Sun, H., Li, X. Q., Wang, H., Zhang, X. P., ... & Wang, H. Y. (2023). MiR-199a-3p promotes repair of myocardial infarction by targeting NACC2. International Journal of Clinical and Experimental Pathology, 16(3), 57.

Yang, W. (2023). Critical Domains for NACC2-NTRK2 Fusion Protein Activation (Doctoral dissertation, UC San Diego).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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