Sign in or Register   Sign in or Register
  |  

Mouse Anti-NAIP Recombinant Antibody (CBWJN-1160) (CBMAB-N1083-WJ)

This product is a Mouse antibody that recognizes NAIP. The antibody CBWJN-1160 can be used for immunoassay techniques such as: WB, IHC.
See all NAIP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1160
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR Family Apoptosis Inhibitory Protein
Introduction
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Entrez Gene ID
4671
UniProt ID
Q13075
Alternative Names
NLR Family Apoptosis Inhibitory Protein; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And BIR Domain Containing 1; Neuronal Apoptosis Inhibitory Protein; BIRC1; Baculoviral IAP Repeat-Containing Protein 1; Psi Neuronal Apoptosis Inhibitory Protein;
Function
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
Biological Process
Defense response to bacterium Source: GO_Central
Detection of bacterium Source: GO_Central
Icosanoid biosynthetic process Source: ComplexPortal
Inflammatory response Source: GO_Central
Innate immune response Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Nervous system development Source: ProtInc
Pattern recognition receptor signaling pathway Source: ComplexPortal
Positive regulation of inflammatory response Source: ComplexPortal
Positive regulation of interleukin-1 beta production Source: ComplexPortal
Positive regulation of JNK cascade Source: UniProtKB
Pyroptosis Source: GO_Central
Regulation of apoptotic process Source: UniProtKB
Cellular Location
Cytosol
inflammasome complex
IPAF inflammasome complex
Plasma Membrane
basolateral plasma membrane
Other locations
cytoplasm
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NAIP Recombinant Antibody (CBWJN-1160)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare