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Mouse Anti-NAP1L1 Recombinant Antibody (CBWJN-0307) (CBMAB-N1143-WJ)

This product is a Mouse antibody that recognizes NAP1L1. The antibody CBWJN-0307 can be used for immunoassay techniques such as: WB, Dot.
See all NAP1L1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-0307
Antibody Isotype
IgG1
Application
WB, Dot

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nucleosome assembly protein 1-like 1
Introduction
This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Entrez Gene ID
Human4673
Mouse53605
Rat89825
UniProt ID
HumanP55209
MouseP28656
RatQ9Z2G8
Alternative Names
Nucleosome Assembly Protein 1 Like 1; Nucleosome Assembly Protein 1-Like 1; NAP-1-Related Protein; NRP; HSP22-Like Protein Interacting Protein; NAP1L; NAP1; HNRP;
Function
Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:26841755).

Participates also in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616).

Stimulates also homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879).

Plays a key role in the regulation of embryonic neurogenesis (By similarity).

Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity).

Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity).

(Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression.

(Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA.
Biological Process
DNA replication Source: ProtInc
Nucleosome assembly Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of neural precursor cell proliferation Source: UniProtKB
Positive regulation of neurogenesis Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Other locations
Melanosome
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PTM
Monoglycylated on glutamate residues. Cannot be polyglycylated due to the absence of functional TTLL10 in human (By similarity).
Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and monoglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally.

Shen, B., Zhu, W., Liu, X., & Jiang, J. (2022). NAP1L1 Functions as a Novel Prognostic Biomarker Associated With Macrophages and Promotes Tumor Progression by Influencing the Wnt/β-Catenin Pathway in Hepatocellular Carcinoma. Frontiers in Genetics, 13, 876253.

Freitag, M., & Schwertz, H. (2022). A new role of NAP1L1 in megakaryocytes and human platelets. International Journal of Molecular Sciences, 23(23), 14694.

Zhu, X., Xie, Y., Huang, W., Chen, Z., & Guo, S. (2022). NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer. BMC cancer, 22(1), 1-10.

Liu, Y., Li, X., Zhang, Y., Tang, Y., Fang, W., Liu, X., & Liu, Z. (2021). NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma. Biomedicine & Pharmacotherapy, 143, 112096.

Liu, S., Zhang, Y., Cui, S., Song, D., Li, B., Chen, Q., ... & Gong, B. (2021). NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth. Cancer Cell International, 21(1), 1-16.

Chen, Z., Xie, Y., Luo, H., Song, Y., Que, T., Hu, R., ... & Luo, Q. (2021). NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun. Aging (Albany NY), 13(24), 26180.

Queiroz, C. J., Song, F., Reed, K. R., Al-Khafaji, N., Clarke, A. R., Vimalachandran, D., ... & Jenkins, J. R. (2020). NAP1L1: a novel human colorectal cancer biomarker derived from animal models of Apc Inactivation. Frontiers in Oncology, 10, 1565.

Nagashio, R., Kuchitsu, Y., Igawa, S., Kusuhara, S., Naoki, K., Satoh, Y., ... & Sato, Y. (2020). Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma. Biomedical Research, 41(3), 149-159.

Tanaka, T., Hozumi, Y., Martelli, A. M., Iino, M., & Goto, K. (2019). Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866(12), 118560.

Le, Y., Kan, A., Li, Q. J., He, M. K., Chen, H. L., & Shi, M. (2019). NAP1L1 is a prognostic biomarker and contribute to doxorubicin chemotherapy resistance in human hepatocellular carcinoma. Cancer cell international, 19(1), 1-11.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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