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Mouse Anti-NAPRT1 Recombinant Antibody (A1291) (CBMAB-AP12452LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
A1291
Antibody Isotype
IgG2a
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of NAPRT1
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nicotinate Phosphoribosyltransferase
Entrez Gene ID
Human93100
Mouse223646
UniProt ID
HumanQ6XQN6
MouseQ8CC86
Alternative Names
FHA HIT interacting protein,FHIP,NAPRT1,NAPRTase,PP3856
Function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198).

Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).
Biological Process
NAD salvage Source: GO_Central
Response to oxidative stress Source: UniProtKB
Cellular Location
Cytosol
PTM
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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