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Rabbit Anti-NAT2 Recombinant Antibody (CBWJN-1179) (CBMAB-N1221-WJ)

This product is a Rabbit antibody that recognizes NAT2. The antibody CBWJN-1179 can be used for immunoassay techniques such as: WB, ICC.
See all NAT2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJN-1179
Antibody Isotype
IgG
Application
WB, ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.511 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Introduction
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Entrez Gene ID
10
UniProt ID
P11245
Alternative Names
N-Acetyltransferase 2; N-Acetyltransferase 2 (Arylamine N-Acetyltransferase); Arylamine N-Acetyltransferase 2; N-Acetyltransferase Type 2; Arylamide Acetylase 2; EC 2.3.1.5;
Function
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Biological Process
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cytoplasm

Thomas, L., Raju, A. P., Kulavalli, S., Varma, M., SV, C. S., Banerjee, M., ... & Rao, M. (2024). Influence of N-acetyltransferase 2 polymorphisms and clinical variables on liver function profile of tuberculosis patients. Expert Review of Clinical Pharmacology, (just-accepted).

Lopes, M. Q. P., Teixeira, R. L. F., Cabello, P. H., Nery, J. A. C., Sales, A. M., JR, E. P. N., ... & Santos, A. R. (2023). Human N-acetyltransferase 2 (NAT2) gene variability in Brazilian populations from different geographical areas. Frontiers in Pharmacology, 14.

Cheng, F., Jiang, X. G., Zheng, S. L., Wu, T., Zhang, Q., Ye, X. C., ... & Shi, J. C. (2023). N-acetyltransferase 2 genetic polymorphisms and anti-tuberculosis-drug-induced liver injury: a correlation study. Frontiers in Pharmacology, 14.

Thomas, L., Raju, A. P., Chaithra, Varma, M., Saravu, K., Banerjee, M., ... & Rao, M. (2022). Influence of N-acetyltransferase 2 (NAT2) genotype/single nucleotide polymorphisms on clearance of isoniazid in tuberculosis patients: a systematic review of population pharmacokinetic models. European Journal of Clinical Pharmacology, 78(10), 1535-1553.

Habil, M. R., Salazar-González, R. A., Doll, M. A., & Hein, D. W. (2022). N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes. Archives of Toxicology, 96(12), 3257-3263.

Fukunaga, K., Kato, K., Okusaka, T., Saito, T., Ikeda, M., Yoshida, T., ... & Mushiroda, T. (2021). Functional characterization of the effects of N-acetyltransferase 2 alleles on N-acetylation of eight drugs and worldwide distribution of substrate-specific diversity. Frontiers in Genetics, 12, 652704.

Yuliwulandari, R., Prayuni, K., Razari, I., Susilowati, R. W., Zulhamidah, Y., Soedarsono, S., ... & Tokunaga, K. (2021). Genetic characterization of N-acetyltransferase 2 variants in acquired multidrug-resistant tuberculosis in Indonesia. Pharmacogenomics, 22(03), 157-163.

Conway, L. P., Rendo, V., Correia, M. S., Bergdahl, I. A., Sjöblom, T., & Globisch, D. (2020). Unexpected acetylation of endogenous aliphatic amines by arylamine N‐acetyltransferase NAT2. Angewandte chemie international edition, 59(34), 14342-14346.

Song, Y., Qi, X., & Liu, X. (2020). N-acetyltransferase 2 polymorphism is associated with bladder cancer risk: An updated meta-analysis based on 54 case-control studies. Gene, 757, 144924.

Saleh, S. A. E. R., Zaghla, H. M. A., Bawady, S. A. H., Kotb, M., & Hammad, W. I. (2019). Assessment of N-acetyltransferase 2 (NAT2) gene polymorphisms in bladder cancer patients. Journal of Nephropharmacology, 8(2), e30-e30.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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