Mouse Anti-NAV2 Recombinant Antibody (4D11) (CBMAB-N1235-WJ)

This product is a Mouse antibody that recognizes NAV2. The antibody 4D11 can be used for immunoassay techniques such as: ELISA, WB.
See all NAV2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4D11

Antibody Isotype

IgG2a

Application

ELISA, WB

Basic Information

Immunogen

NAV2 (1878 a.a. ~ 1973 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

neuron navigator 2

Introduction

This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Entrez Gene ID

89797

UniProt ID

Q8IVL1

Alternative Names

Neuron Navigator 2; Pore Membrane And/Or Filament-Interacting-Like Protein 2; Retinoic Acid Inducible Gene In Neuroblastoma 1; Helicase, APC Down-Regulated 1; Unc-53 Homolog 2; Steerin-2; STEERIN2; UNC53H2; POMFIL2;

Function

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.

Biological Process

Glossopharyngeal nerve development Source: Ensembl
Locomotory behavior Source: Ensembl
Nervous system development Source: GO_Central
Neurogenesis Source: InterPro
Optic nerve development Source: Ensembl
Regulation of systemic arterial blood pressure by baroreceptor feedback Source: Ensembl
Sensory perception of smell Source: Ensembl
Sensory perception of sound Source: Ensembl
Vagus nerve development Source: Ensembl

Cellular Location

Nucleus

References

Accogli, A., Lu, S., Musante, I., Scudieri, P., Rosenfeld, J. A., Severino, M., ... & Salpietro, V. (2023). Loss of neuron navigator 2 impairs brain and cerebellar development. The Cerebellum, 22(2), 206-222.

Wang, R., Li, M., Ding, Q., Cai, J., Yu, Y., Liu, X., ... & Zhu, Y. Z. (2021). Neuron navigator 2 is a novel mediator of rheumatoid arthritis. Cellular & Molecular Immunology, 18(9), 2288-2289.

Xu, C., Su, B. B., Lozano, S., & Wang, K. (2020). The neuron navigator 2 gene and Alzheimer's disease. Genetics, Neurology, Behavior, and Diet in Dementia, 3-24.

Hu, W., Li, X., Cheng, R., Ke, J., Liu, Y., Ma, M., ... & Liu, D. (2019). NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway. Archives of Dermatological Research, 311, 399-410.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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