Mouse Anti-NBEA Recombinant Antibody (3F11) (CBMAB-N1237-WJ)

Name: Mouse Anti-NBEA Recombinant Antibody (3F11)
SKU: CBMAB-N1237-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F11

Application

ELISA, IF, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

neurobeachin

Introduction

This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]

Entrez Gene ID

26960

UniProt ID

Q8NFP9

Alternative Names

Neurobeachin; Lysosomal-Trafficking Regulator 2; BCL8B; LYST2; Protein BCL8B; EC 1.14.14.5; EC 6.1.1.11; KIAA1544;

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).

Biological Process

Protein localization Source: GO_Central

Cellular Location

Cytoplasm
Other locations
Membrane

Involvement in disease

Neurodevelopmental disorder with or without early-onset generalized epilepsy (NEDEGE):
An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, variably impaired intellectual development, speech delay, and behavioral abnormalities including autism or autistic features, attention deficits and hyperactivity, or aggressive behavior. About half of patients develop early-onset generalized epilepsy with different seizure types. The disease is apparent from infancy or early childhood.

Dukkipati, S., & Starr, L. (2023). P155: NBEA-related neurodevelopmental disease: expansion of the phenotype and second patient with clinical images. Genetics in Medicine Open, 1(1).

Lützenkirchen, F., Zhu, Y., Maric, H., Gromova, K., & Kneussel, M. (2023). NEUROBEACHIN MEDIATES ACTIVITY-DEPENDENT CHANGES AT GABAERGIC SYNAPSES. IBRO Neuroscience Reports, 15, S317-S318.

Martin, E. A., Michel, J. C., Kissinger, J. S., Echeverry, F. A., Lin, Y. P., O’Brien, J., ... & Miller, A. C. (2023). Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins. Current Biology, 33(10), 2063-2074.

Budniok, S., Odent, P., Callaerts-Vegh, Z., Bosmans, G., & D’Hooge, R. (2023). Neurobeachin haploinsufficient mice display sex-independent alterations in cued and contextual fear conditioning. NeuroReport, 34(13), 664-669.

Mohammed, S., & Qoronfleh, M. W. (2022). Autism and the Scaffolding Protein Neurobeachin. In Proteins Associated with Neurodevelopmental Disorders (pp. 277-289). Singapore: Springer Singapore.

Cuzon Carlson, V. C., Aylwin, C. F., Carlson, T. L., Ford, M., Mesnaoui, H., Lomniczi, A., ... & Cervera‐Juanes, R. P. (2022). Neurobeachin, a promising target for use in the treatment of alcohol use disorder. Addiction biology, 27(1), e13107.

Boulin, T., Itani, O., El Mouridi, S., Leclercq-Blondel, A., Gendrel, M., Macnamara, E., ... & Pak, S. C. (2021). Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA. Molecular Genetics and Metabolism, 134(1-2), 195-202.

Odent, P., Creemers, J. W., Bosmans, G., & D’Hooge, R. (2021). Spectrum of social alterations in the Neurobeachin haploinsufficiency mouse model of autism. Brain Research Bulletin, 167, 11-21.

Liang, Q., Xu, H., Liu, Y., Zhang, W., Sun, C., Hu, M., ... & Liu, L. (2021). Coexistence of a novel NBEA-ALK, EML4-ALK double-fusion in a lung adenocarcinoma patient and response to alectinib: a case report. Lung Cancer, 162, 86-89.

Muellerleile, J., Blistein, A., Rohlmann, A., Scheiwe, F., Missler, M., Schwarzacher, S. W., & Jedlicka, P. (2020). Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin. Scientific Reports, 10(1), 16058.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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