Mouse Anti-NCDN Recombinant Antibody (1C7) (CBMAB-1612-CN)

Name: Mouse Anti-NCDN Recombinant Antibody (1C7)
SKU: CBMAB-1612-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C7

Application

ELISA

Immunogen

NCDN (NP_001014839, aa. 312-412) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

neurochondrin

Introduction

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity).

Entrez Gene ID

23154

UniProt ID

Q9UBB6

Alternative Names

neurochondrin

Function

Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248).

Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).

Biological Process

Bone resorption Source: Ensembl
Neuron projection development Source: UniProtKB
Regulation of neuronal synaptic plasticity Source: GO_Central

Cellular Location

Endosome
Endosome membrane
cytosol
Other locations
dendrite
postsynapse
Note: Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.

Involvement in disease

Neurodevelopmental disorder with infantile epileptic spasms (NEDIES):
An autosomal dominant neurodevelopmental disorder characterized by onset of severe and frequent epileptic spasms within the first year of life. Affected individuals have global developmental delay with delayed walking and poor or absent speech. More variable features may include poor overall growth, high-arched palate, and delayed myelination on brain imaging.

PTM

Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.

Montalban, E., Giralt, A., Taing, L., Nakamura, Y., Pelosi, A., Brown, M., ... & Girault, J. A. (2023). Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. bioRxiv, 2023-03.

Nicolas, G., Sévigny, M., Lecoquierre, F., Marguet, F., Deschênes, A., Del Pelaez, M. C., ... & Sephton, C. F. (2022). A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics. Acta neuropathologica communications, 10(1), 20.

Fatima, A., Hoeber, J., Schuster, J., Koshimizu, E., Maya-Gonzalez, C., Keren, B., ... & Dahl, N. (2021). Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy. The American Journal of Human Genetics, 108(4), 739-748.

Fatima, A., Schuster, J., Akram, T., Sobol, M., Hoeber, J., & Dahl, N. (2020). Generation of a human Neurochondrin deficient iPSC line KICRi002-A-3 using CRISPR/Cas9. Stem cell research, 44, 101758.

Weihua, Z., Haitao, R., Fang, F., Xunzhe, Y., Jing, W., & Hongzhi, G. (2019). Neurochondrin antibody serum positivity in three cases of autoimmune cerebellar ataxia. The Cerebellum, 18, 1137-1142.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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