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Mouse Anti-NCDN Recombinant Antibody (1C7) (CBMAB-1612-CN)

This product is a mouse antibody that recognizes NCDN of human. The antibody 1C7 can be used for immunoassay techniques such as: ELISA.
See all NCDN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C7
Antibody Isotype
IgG2a, Κ
Application
ELISA

Basic Information

Immunogen
NCDN (NP_001014839, aa. 312-412) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neurochondrin
Introduction
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity).
Entrez Gene ID
23154
UniProt ID
Q9UBB6
Alternative Names
neurochondrin
Function
Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling (PubMed:33711248).

Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
Biological Process
Bone resorption Source: Ensembl
Neuron projection development Source: UniProtKB
Regulation of neuronal synaptic plasticity Source: GO_Central
Cellular Location
Endosome
Endosome membrane
cytosol
Other locations
dendrite
postsynapse
Note: Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.
Involvement in disease
Neurodevelopmental disorder with infantile epileptic spasms (NEDIES):
An autosomal dominant neurodevelopmental disorder characterized by onset of severe and frequent epileptic spasms within the first year of life. Affected individuals have global developmental delay with delayed walking and poor or absent speech. More variable features may include poor overall growth, high-arched palate, and delayed myelination on brain imaging.
PTM
Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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