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Mouse Anti-NCOA5 Recombinant Antibody (1E9) (CBMAB-N1466-WJ)

This product is a Mouse antibody that recognizes NCOA5. The antibody 1E9 can be used for immunoassay techniques such as: ELISA.
See all NCOA5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E9
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear receptor coactivator 5
Introduction
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Entrez Gene ID
57727
UniProt ID
Q9HCD5
Alternative Names
Nuclear Receptor Coactivator 5; Coactivator Independent Of AF-2; NCoA-5; CIA; BA465L10.6; KIAA1637;
Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Biological Process
Glucose homeostasis Source: Ensembl
Negative regulation of insulin receptor signaling pathway Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of signal transduction Source: GO_Central

Zhang, Y., Luo, Y., Liu, X., Kiupel, M., Li, A., Wang, H., ... & Xiao, H. (2024). NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma. Cellular and Molecular Gastroenterology and Hepatology, 17(1), 1-27.

Liu, Y., & Feng, G. S. (2024). NCOA5 Deficiency in Macrophages Provokes NASH and HCC. Cellular and Molecular Gastroenterology and Hepatology, 17(1), 171-172.

Wang, T., Zhang, F., & Zhang, P. (2023). Role of the TPX2/NCOA5 axis in regulating proliferation, migration, invasion and angiogenesis of breast cancer cells. Experimental and Therapeutic Medicine, 25(6), 1-10.

Song, X., Qian, D., Dai, P., Li, Q., Xi, Q., & Sun, K. (2023). Expression and clinical significance of NCOA5 in epithelial ovarian cancer. Frontiers in Oncology, 13, 1117033.

Rustemoglu, H., Arslan, E., Atasever, S., Cevik, B., Taspinar, F., Turhan, A. B., & Rustemoglu, A. (2023). Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?. Molecular Biology Reports, 50(11), 9335-9341.

Tan, Y., Liu, F., & Xu, P. (2021). Knockdown of NCOA5 suppresses viability, migration and epithelial‑mesenchymal transition, and induces adhesion of breast cancer cells. Oncology Letters, 22(4), 1-7.

Yuan, X., Zhang, L., Cui, Y., Yu, Y., Gao, X., & Ao, J. (2020). NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells. Biochemical and Biophysical Research Communications, 529(3), 569-574.

Williams, M., Liu, X., Zhang, Y., Reske, J., Bahal, D., Gohl, T. G., ... & Xiao, H. (2020). NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21WAF1/CIP1 overexpression, which is reversed by metformin. Oncogene, 39(19), 3821-3836.

Liang, Y., Zhang, T., Shi, M., Zhang, S., Guo, Y., Gao, J., & Yang, X. (2019). Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway. Journal of Cellular Biochemistry, 120(4), 6237-6249.

Gao, S., Zhang, Y., Yang, C., Perez, G. I., & Xiao, H. (2019). NCOA5 haplo-insufficiency results in male mouse infertility through increased IL-6 expression in the epididymis. Scientific Reports, 9(1), 15525.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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