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Mouse Anti-NDUFA13 Recombinant Antibody (CBLG1-3232) (CBMAB-G6397-LY)

This product is antibody recognizes NDUFA13. The antibody CBLG1-3232 immunoassay techniques such as: WB.
See all NDUFA13 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBLG1-3232
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NADH:Ubiquinone Oxidoreductase Subunit A13
Introduction
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Entrez Gene ID
Human51079
Mouse67184
Rat100911483
UniProt ID
HumanQ9P0J0
MouseQ9ERS2
RatD3ZE15
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371).

Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).

Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091).
Biological Process
Aerobic respiration Source: ComplexPortal
Apoptotic signaling pathway Source: UniProtKB
Cellular response to interferon-beta Source: ParkinsonsUK-UCL
Cellular response to retinoic acid Source: ParkinsonsUK-UCL
Electron transport chain Source: GOC
Extrinsic apoptotic signaling pathway Source: Ensembl
Mitochondrial ATP synthesis coupled proton transport Source: ComplexPortal
Mitochondrial respiratory chain complex I assembly Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
Positive regulation of peptidase activity Source: ParkinsonsUK-UCL
Positive regulation of protein catabolic process Source: ParkinsonsUK-UCL
Protein insertion into mitochondrial inner membrane Source: UniProtKB
Reactive oxygen species metabolic process Source: UniProtKB
Cellular Location
Mitochondrion
Mitochondrion inner membrane
Nucleus
Note: Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment.
Involvement in disease
Hurthle cell thyroid carcinoma (HCTC):
A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.
Mitochondrial complex I deficiency, nuclear type 28 (MC1DN28):
A form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN28 transmission pattern is consistent with autosomal recessive inheritance.
Topology
Helical: 30-51
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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