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Mouse Anti-NDUFA4L2 Recombinant Antibody (CF305) (CBMAB-FT204LY)

The product is antibody recognizes NDUFA4L2 . The antibody CF305 immunoassay techniques such as: ELISA, WB, IHC, IF.
See all NDUFA4L2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF305
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC, IF

Basic Information

Immunogen
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NDUFA4, Mitochondrial Complex Associated Like 2
Introduction
NDUFA4L2 (NDUFA4, Mitochondrial Complex Associated Like 2) is a Protein Coding gene. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is NDUFA4.
Entrez Gene ID
56901
UniProt ID
Q9NRX3
Cellular Location
Mitochondrial respiratory chain complex IV

Mei, Q., Chen, P., Lv, Y., Zheng, L., Liu, D., Zhang, M., ... & Li, P. (2024). Elevated of NDUFA4L2 expression in colon adenocarcinoma is correlated with an unfavorable prognosis and increased immune cell infiltration. Heliyon.

Kubala, J. M., Laursen, K. B., Schreiner, R., Williams, R. M., van der Mijn, J. C., Crowley, M. J., ... & Gudas, L. J. (2023). NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer Biology & Therapy, 24(1), 2170669.

Mesa-Ciller, C., Turiel, G., Guajardo-Grence, A., Lopez-Rodriguez, A. B., Egea, J., De Bock, K., ... & Urrutia, A. A. (2023). Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia. Journal of Cerebral Blood Flow & Metabolism, 43(1), 44-58.

Liu, Y., Nie, X., Zhu, J., Wang, T., Li, Y., Wang, Q., & Sun, Z. (2021). NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension. Journal of Cellular and Molecular Medicine, 25(2), 1221-1237.

Liu, Z., Chaillou, T., Santos Alves, E., Mader, T., Jude, B., Ferreira, D. M., ... & Lanner, J. T. (2021). Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. The FASEB Journal, 35(12), e22010.

Yuan, Y., Gao, H., Zhuang, Y., Wei, L., Yu, J., Zhang, Z., ... & Wang, L. (2021). NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer. Therapeutic Advances in Medical Oncology, 13, 17588359211027836.

Chen, Z., Wei, X., Wang, X., Zheng, X., Chang, B., Shen, L., ... & Zheng, X. (2021). NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death & Disease, 12(4), 377.

Xu, W. N., Yang, R. Z., Zheng, H. L., Jiang, L. S., & Jiang, S. D. (2020). NDUFA4L2 regulated by HIF-1α promotes metastasis and epithelial–mesenchymal transition of osteosarcoma cells through inhibiting ROS production. Frontiers in cell and developmental biology, 8, 515051.

Xu, W. N., Zheng, H. L., Yang, R. Z., Liu, T., Yu, W., Zheng, X. F., ... & Jiang, L. S. (2019). Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy. Experimental & molecular medicine, 51(11), 1-16.

Meng, L., Yang, X., Xie, X., & Wang, M. (2019). Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress. Thoracic Cancer, 10(4), 676-685.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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