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Mouse Anti-NDUFAF7 Recombinant Antibody (CBYY-C0804) (CBMAB-C2240-YY)

This product is mouse antibody that recognizes NDUFAF7. The antibody CBYY-C0804 can be used for immunoassay techniques such as: WB, IHC, IF
See all NDUFAF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Dog, Monkey
Clone
CBYY-C0804
Antibody Isotype
IgG2a
Application
WB, IHC, IF

Basic Information

Immunogen
Full length human recombinant protein of human C2orf62 (NP_940961) produced in HEK293T cell
Specificity
Human, Mouse, Rat, Dog, Monkey
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 7
Entrez Gene ID
Human55471
Mouse73694
Rat298748
Dog475725
Monkey709473
UniProt ID
HumanQ7L592
MouseQ9CWG8
RatQ5XI79
DogE2R8S9
MonkeyG7N9U5
Alternative Names
Carbonic Anhydrase 12; Carbonic Anhydrase XII; Tumor Antigen HOM-RCC-3.1.3; Carbonate Dehydratase XII; CA-XII; Carbonic Dehydratase;
Function
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397).

Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531).
Biological Process
Mitochondrial respiratory chain complex I assembly Source: UniProtKB
Peptidyl-arginine methylation, to symmetrical-dimethyl arginine Source: UniProtKB
Cellular Location
Mitochondrion
Involvement in disease
Defects in NDUFAF7 may be a cause of susceptibility to pathologic myopia, a genetically heterogeneous disorder characterized by extreme, familial, early-onset vision loss and described as myopia accompanied by severe deformation of the eye besides excessive elongation of the eye.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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