Mouse Anti-NDUFV2 Recombinant Antibody (1A10) (CBMAB-N1701-WJ)

Name: Mouse Anti-NDUFV2 Recombinant Antibody (1A10)
SKU: CBMAB-N1701-WJ
Rating: 5 (1 reviews)

See all NDUFV2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A10

Application

ELISA, WB

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NADH:Ubiquinone Oxidoreductase Core Subunit V2

Introduction

The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]

Entrez Gene ID

Human	4729
Mouse	72900
Rat	81728

UniProt ID

Human	P19404
Mouse	Q9D6J6
Rat	P19234

Alternative Names

NADH:Ubiquinone Oxidoreductase Core Subunit V2; NADH Dehydrogenase [Ubiquinone] Flavoprotein 2, Mitochondrial; NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa; NADH-Ubiquinone Oxidoreductase 24 KDa Subunit; Complex I 24kDa Subunit; Nuclear-Encoded Mitochondrial NADH-Ubiquinone Reductase 24Kd Subunit; NADH Dehydrogenase Ubiquinone Flavoprotein 2, Mitochondrial;

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

Biological Process

Aerobic respiration Source: ComplexPortal
Cardiac muscle tissue development Source: UniProtKB
Mitochondrial ATP synthesis coupled proton transport Source: ComplexPortal
Mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
Nervous system development Source: UniProtKB

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Mitochondrial complex I deficiency, nuclear type 7 (MC1DN7):
A form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN7 transmission pattern is consistent with autosomal recessive inheritance.

Yang, M., Abudureyimu, M., Wang, X., Zhou, Y., Zhang, Y., & Ren, J. (2023). PHB2 ameliorates Doxorubicin-induced cardiomyopathy through interaction with NDUFV2 and restoration of mitochondrial complex I function. Redox biology, 65, 102812.

Liu, Z., Zhang, L., Ren, C., Xu, M., Li, S., Ban, R., ... & Fang, F. (2022). Whole genome and exome sequencing identify NDUFV2 mutations as a new cause of progressive cavitating leukoencephalopathy. Journal of Medical Genetics, 59(4), 351-357.

Wang, Z., Chen, L., Li, Q., Zhang, H., Shan, Y., Qi, L., ... & Chen, Y. (2022). Association between single-nucleotide polymorphism rs145497186 related to NDUFV2 and lumbar disc degeneration: a pilot case–control study. Journal of Orthopaedic Surgery and Research, 17(1), 1-8.

Liu, L., Wang, X., Li, Y., Ma, C., Shi, Y., Li, X., & Chen, J. (2022). The NDUFV2 gene silencing inhibits the proliferation of two drug-resistant cancer cell lines. Journal of Genetic Engineering and Biotechnology, 20(1), 1-8.

Zhang, H., Shao, Y., Chen, W., & Chen, X. (2021). Identifying mitochondrial-related genes NDUFA10 and NDUFV2 as prognostic markers for prostate cancer through biclustering. BioMed Research International, 2021, 1-15.

Pamplona, R., Jové, M., Mota‐Martorell, N., & Barja, G. (2021). Is the NDUFV2 subunit of the hydrophilic complex I domain a key determinant of animal longevity?. The FEBS Journal, 288(23), 6652-6673.

Chella Krishnan, K., Vergnes, L., Acín-Pérez, R., Stiles, L., Shum, M., Ma, L., ... & Lusis, A. J. (2021). Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2. Nature metabolism, 3(11), 1552-1568.

Kishita, Y., Shimura, M., Kohda, M., Fushimi, T., Nitta, K. R., Yatsuka, Y., ... & Okazaki, Y. (2021). Genome sequencing and RNA‐seq analyses of mitochondrial complex I deficiency revealed Alu insertion‐mediated deletion in NDUFV2. Human Mutation, 42(11), 1422-1428.

Bergman, O., Karry, R., Milhem, J., & Ben-Shachar, D. (2020). NDUFV2 pseudogene (NDUFV2P1) contributes to mitochondrial complex I deficits in schizophrenia. Molecular Psychiatry, 25(4), 805-820.

Mota-Martorell, N., Jove, M., Pradas, I., Sanchez, I., Gómez, J., Naudi, A., ... & Pamplona, R. (2020). Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity. Redox Biology, 34, 101539.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NDUFV2 Recombinant Antibody (1A10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-NDUFV2 Recombinant Antibody (H-7) (CAT#: CBMAB-N1705-WJ)

Mouse Anti-NDUFV2 Recombinant Antibody (B-11) (CAT#: CBMAB-N1702-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry