Sign in or Register   Sign in or Register
  |  

Mouse Anti-NETO2 Recombinant Antibody (3E3) (CBMAB-N2006-WJ)

This product is a Mouse antibody that recognizes NETO2. The antibody 3E3 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all NETO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E3
Antibody Isotype
IgG2a, κ
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
neuropilin (NRP) and tolloid (TLL)-like 2
Introduction
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
81831
UniProt ID
Q8NC67
Alternative Names
Neuropilin And Tolloid Like 2; Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 2; Neuropilin (NRP) And Tolloid (TLL)-Like 2; BTCL2; Neuropilin And Tolloid-Like Protein 2; NEOT2;
Function
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).
Biological Process
Regulation of kainate selective glutamate receptor activity Source: InterPro
Cellular Location
Membrane
Topology
Extracellular: 23-347
Helical: 348-368
Cytoplasmic: 369-525
PTM
N-glycosylated.

Zhu, S., Zhang, X., Guo, Y., Tang, L., Zhou, Z., Chen, X., & Peng, C. (2023). NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway. Frontiers of Medicine, 1-12.

Zhang, Z., Wang, J., Zhang, X., Ran, B., Wen, J., & Zhang, H. (2023). TYMSOS-miR-101-3p-NETO2 axis promotes osteosarcoma progression. Molecular and Cellular Probes, 67, 101887.

He, L., Sun, J., Gao, Y., Li, B., Wang, Y., Dong, Y., ... & Zhao, Y. (2021). Kainate receptor modulation by NETO2. Nature, 599(7884), 325-329.

Wang, X., Bian, Z., Hou, C., Li, M., Jiang, W., & Zhu, L. (2021). Neuropilin and tolloid-like 2 regulates the progression of osteosarcoma. Gene, 768, 145292.

Xu, J. C., Chen, T. Y., Liao, L. T., Chen, T., Li, Q. L., Xu, J. X., ... & Zhang, Y. Q. (2021). NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway. International Journal of Biological Sciences, 17(1), 259.

Fedorova, M. S., Snezhkina, A. V., Lipatova, A. V., Pavlov, V. S., Kobelyatskaya, A. A., Guvatova, Z. G., ... & Kudryavtseva, A. V. (2020). NETO2 Is Deregulated in Breast, Prostate, and Colorectal Cancer and Participates in Cellular Signaling. Frontiers in genetics, 11, 594933.

Li, Y., Zhang, Y., & Liu, J. (2019). NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway. Cancer Management and Research, 5147-5156.

He, A. R., Zhu, Q., & Gao, S. (2019). Reducing NETO2 expression prevents human nasopharyngeal carcinoma (NPC) progression by suppressing metastasis and inducing apoptosis. Biochemical and biophysical research communications, 513(2), 494-501.

Liu, J. Y., Jiang, L., He, T., Liu, J. J., Fan, J. Y., Xu, X. H., ... & Yu, P. W. (2019). NETO2 promotes invasion and metastasis of gastric cancer cells via activation of PI3K/Akt/NF-κB/Snail axis and predicts outcome of the patients. Cell death & disease, 10(3), 162.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NETO2 Recombinant Antibody (3E3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare