Mouse Anti-NGF Recombinant Antibody (A1355) (CBMAB-AP5024LY)

Nerve Growth Factor

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5;

L148M

Activation of cysteine-type endopeptidase activity involved in apoptotic processIGI:ARUK-UCL
Extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ARUK-UCL
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Neuron apoptotic processIGI:ARUK-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIDA:MGI
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of collateral sproutingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of DNA bindingBy SimilarityISS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron differentiationManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of Ras protein signal transductionISS:ParkinsonsUK-UCL
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Secreted
Endosome lumen
ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.