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Mouse Anti-NGF Recombinant Antibody (A1356) (CBMAB-AP5027LY)


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Summary

Host Animal
Mouse
Specificity
Cattle, Human, Mouse, Viper
Clone
A1356
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Human recombinant nerve growth factor (hNGF).
Specificity
Cattle, Human, Mouse, Viper
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4803
Mouse18049
Cattle281350
UniProt ID
HumanP01138
MouseP01139
CattleP13600
Alternative Names
Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5;
Function
L149M
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processIGI:ARUK-UCL
Extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
MemoryManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ARUK-UCL
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Nerve developmentManual Assertion Based On ExperimentIBA:GO_Central
Nerve growth factor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Neuron apoptotic processIGI:ARUK-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIDA:MGI
Peripheral nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of collateral sproutingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of DNA bindingBy SimilarityISS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron differentiationManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of Ras protein signal transductionISS:ParkinsonsUK-UCL
Regulation of neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Endosome lumen
ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 5 (HSAN5):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
More Infomation

Santucci, D., Racca, A., & Alleva, E. (2021). When nerve growth factor met behavior. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 205-214.

Maranesi, M., Boiti, C., & Zerani, M. (2021). Nerve growth factor (NGF) and animal reproduction. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 277-287.

Mitra, S., Gera, R., Linderoth, B., Lind, G., Wahlberg, L., Almqvist, P., ... & Eriksdotter, M. (2021). A review of techniques for biodelivery of nerve growth factor (NGF) to the brain in relation to Alzheimer’s disease. Recent Advances in NGF and Related Molecules: The Continuum of the NGF “Saga”, 167-191.

Oo, W. M., & Hunter, D. J. (2021). Nerve growth factor (NGF) inhibitors and related agents for chronic musculoskeletal pain: a comprehensive review. BioDrugs, 35, 611-641.

Zha, K., Yang, Y., Tian, G., Sun, Z., Yang, Z., Li, X., ... & Guo, Q. (2021). Nerve growth factor (NGF) and NGF receptors in mesenchymal stem/stromal cells: Impact on potential therapies. Stem cells translational medicine, 10(7), 1008-1020.

Wise, B. L., Seidel, M. F., & Lane, N. E. (2021). The evolution of nerve growth factor inhibition in clinical medicine. Nature Reviews Rheumatology, 17(1), 34-46.

Barker, P. A., Mantyh, P., Arendt-Nielsen, L., Viktrup, L., & Tive, L. (2020). Nerve growth factor signaling and its contribution to pain. Journal of pain research, 1223-1241.

Ciafrè, S., Ferraguti, G., Tirassa, P., Iannitelli, A., Ralli, M., Greco, A., ... & Fiore, M. (2020). Nerve growth factor in the psychiatric brain. Rivista di psichiatria, 55(1), 4-15.

Li, R., Li, D., Wu, C., Ye, L., Wu, Y., Yuan, Y., ... & Xiao, J. (2020). Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics, 10(4), 1649.

Naletova, I., Satriano, C., Pietropaolo, A., Gianì, F., Pandini, G., Triaca, V., ... & Rizzarelli, E. (2019). The copper (II)-assisted connection between NGF and BDNF by means of nerve growth factor-mimicking short peptides. Cells, 8(4), 301.

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For research use only. Not intended for any clinical use.

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