Mouse Anti-NHLH1 Recombinant Antibody (4D7) (CBMAB-N2429-WJ)

This product is a Mouse antibody that recognizes NHLH1. The antibody 4D7 can be used for immunoassay techniques such as: ELISA, IHC-P.
See all NHLH1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4D7

Antibody Isotype

IgG2a, κ

Application

ELISA, IHC-P

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nescient helix loop helix 1

Introduction

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]

Entrez Gene ID

4807

UniProt ID

Q02575

Alternative Names

Nescient Helix-Loop-Helix 1; Class A Basic Helix-Loop-Helix Protein 35; Nescient Helix Loop Helix 1; BHLHa35; NSCL-1; HEN-1;

Function

May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.

Biological Process

Cell differentiationIEA:UniProtKB-KW
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

References

Ramos, B. G., Ohnmacht, J., de Lange, N., Ginolhac, A., Valceschini, E., Rakovic, A., ... & Sinkkonen, L. (2023). Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiation. bioRxiv, 2023-01.

Ohnmacht, J., de Lange, N., Ginolhac, A., Valceschini, E., Rakovic, A., Halder, R., ... & Sinkkonen, L. (2023). Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiation.

Masuda, A., Ajima, R., Saga, Y., Hirata, T., & Zhu, Y. (2022). Nhlh1 and Nhlh2, a global transcriptional mechanism regulating commissural axon projection via activating Robo3. bioRxiv, 2022-09.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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