Mouse Anti-NKX3-2 Recombinant Antibody (H-4) (CBMAB-N2630-WJ)

Name: Mouse Anti-NKX3-2 Recombinant Antibody (H-4)
SKU: CBMAB-N2630-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

H-4

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NK3 Homeobox 2

Introduction

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

Entrez Gene ID

579

UniProt ID

P78367

Alternative Names

NK3 Homeobox 2; Bagpipe Homeobox Protein Homolog 1; Homeobox Protein NK-3 Homolog B; BAPX1; NKX3B; Bagpipe Homeobox Homolog 1 (Drosophila); Homeobox Protein Nkx-3.2; NKX3.2; SMMD;

Function

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).

Biological Process

Animal organ formationIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryIEA:Ensembl
Embryonic skeletal system developmentIEA:Ensembl
Intestinal epithelial cell developmentIEA:Ensembl
Middle ear morphogenesisIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of chondrocyte differentiationISS:UniProtKB
Pancreas developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Skeletal system morphogenesisIEA:Ensembl
Spleen developmentIEA:Ensembl
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Involvement in disease

Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD):
A skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphyseal ossification centers and wide growth plates in the long tubular bones, and numerous pseudoepiphyses of the short tubular bones in hands and feet.

Bae, A. N., Kim, J., Park, J. H., Lee, J. H., & Choi, E. (2023). Comprehensive Analysis of NKX3. 2 in Liver Hepatocellular Carcinoma by Bigdata. Medicina, 59(10), 1782.

Xu, Q., Luo, Y., Chao, Z., Zhang, J., Liu, X., Tang, Q., ... & Fang, M. (2023). Integrated Analysis of Transcriptome Expression Profiles Reveals miRNA-326–NKX3. 2-Regulated Porcine Chondrocyte Differentiation. International Journal of Molecular Sciences, 24(8), 7257.

Leyhr, J., Waldmann, L., Filipek-Górniok, B., Zhang, H., Allalou, A., & Haitina, T. (2022). A novel cis-regulatory element drives early expression of Nkx3. 2 in the gnathostome primary jaw joint. Elife, 11, e75749.

Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., ... & Crump, J. G. (2021). Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3. 2 in the skeleton. Development, 148(2), dev193409.

Waldmann, L., Leyhr, J., Zhang, H., Öhman-Mägi, C., Allalou, A., & Haitina, T. (2021). The broad role of Nkx3. 2 in the development of the zebrafish axial skeleton. PLoS One, 16(8), e0255953.

Oh, H. K., Park, M., Choi, S. W., Jeong, D. U., Kim, B. J., Kim, J. A., ... & Kim, D. W. (2021). Suppression of Osteoarthritis progression by post-natal Induction of Nkx3. 2. Biochemical and Biophysical Research Communications, 571, 188-194.

Miyashita, T., Baddam, P., Smeeton, J., Oel, A. P., Natarajan, N., Gordon, B., ... & Allison, W. T. (2020). nkx3. 2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish. Journal of Experimental Biology, 223(15), jeb216945.

Simsek-Kiper, P. O., Kosukcu, C., Akgun-Dogan, O., Gocmen, R., Utine, G. E., Soyer, T., ... & Boduroglu, K. (2019). A novel NKX3-2 mutation associated with perinatal lethal phenotype of spondylo-megaepiphyseal-metaphyseal dysplasia in a neonate. European journal of medical genetics, 62(1), 21-26.

Guo, J., Wang, Z., Wu, J., Liu, M., Li, M., Sun, Y., ... & Yi, F. (2019). Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3. 2-GATA5 signaling. Circulation Research, 124(10), 1448-1461.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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