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Mouse Anti-NKX3-2 Recombinant Antibody (H-4) (CBMAB-N2630-WJ)

This product is a Mouse antibody that recognizes NKX3-2. The antibody H-4 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NKX3-2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H-4
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NK3 Homeobox 2
Introduction
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
Entrez Gene ID
579
UniProt ID
P78367
Alternative Names
NK3 Homeobox 2; Bagpipe Homeobox Protein Homolog 1; Homeobox Protein NK-3 Homolog B; BAPX1; NKX3B; Bagpipe Homeobox Homolog 1 (Drosophila); Homeobox Protein Nkx-3.2; NKX3.2; SMMD;
Function
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).
Biological Process
Animal organ formationIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Determination of left/right symmetryIEA:Ensembl
Embryonic skeletal system developmentIEA:Ensembl
Intestinal epithelial cell developmentIEA:Ensembl
Middle ear morphogenesisIEA:Ensembl
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of chondrocyte differentiationISS:UniProtKB
Pancreas developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Skeletal system morphogenesisIEA:Ensembl
Spleen developmentIEA:Ensembl
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD):
A skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphyseal ossification centers and wide growth plates in the long tubular bones, and numerous pseudoepiphyses of the short tubular bones in hands and feet.

Bae, A. N., Kim, J., Park, J. H., Lee, J. H., & Choi, E. (2023). Comprehensive Analysis of NKX3. 2 in Liver Hepatocellular Carcinoma by Bigdata. Medicina, 59(10), 1782.

Xu, Q., Luo, Y., Chao, Z., Zhang, J., Liu, X., Tang, Q., ... & Fang, M. (2023). Integrated Analysis of Transcriptome Expression Profiles Reveals miRNA-326–NKX3. 2-Regulated Porcine Chondrocyte Differentiation. International Journal of Molecular Sciences, 24(8), 7257.

Leyhr, J., Waldmann, L., Filipek-Górniok, B., Zhang, H., Allalou, A., & Haitina, T. (2022). A novel cis-regulatory element drives early expression of Nkx3. 2 in the gnathostome primary jaw joint. Elife, 11, e75749.

Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., ... & Crump, J. G. (2021). Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3. 2 in the skeleton. Development, 148(2), dev193409.

Waldmann, L., Leyhr, J., Zhang, H., Öhman-Mägi, C., Allalou, A., & Haitina, T. (2021). The broad role of Nkx3. 2 in the development of the zebrafish axial skeleton. PLoS One, 16(8), e0255953.

Oh, H. K., Park, M., Choi, S. W., Jeong, D. U., Kim, B. J., Kim, J. A., ... & Kim, D. W. (2021). Suppression of Osteoarthritis progression by post-natal Induction of Nkx3. 2. Biochemical and Biophysical Research Communications, 571, 188-194.

Miyashita, T., Baddam, P., Smeeton, J., Oel, A. P., Natarajan, N., Gordon, B., ... & Allison, W. T. (2020). nkx3. 2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish. Journal of Experimental Biology, 223(15), jeb216945.

Simsek-Kiper, P. O., Kosukcu, C., Akgun-Dogan, O., Gocmen, R., Utine, G. E., Soyer, T., ... & Boduroglu, K. (2019). A novel NKX3-2 mutation associated with perinatal lethal phenotype of spondylo-megaepiphyseal-metaphyseal dysplasia in a neonate. European journal of medical genetics, 62(1), 21-26.

Guo, J., Wang, Z., Wu, J., Liu, M., Li, M., Sun, Y., ... & Yi, F. (2019). Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3. 2-GATA5 signaling. Circulation Research, 124(10), 1448-1461.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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