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Mouse Anti-NLRP5 Recombinant Antibody (C-3) (CBMAB-N2707-WJ)

This product is a Mouse antibody that recognizes NLRP5. The antibody C-3 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NLRP5 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
C-3
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NLR FAMILY PYRIN DOMAIN CONTAINING 5
Introduction
The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
126206
UniProt ID
P59047
Alternative Names
NLR Family Pyrin Domain Containing 5; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 5; NACHT, Leucine Rich Repeat And PYD Containing 5; Maternal Antigen That Embryos Require; Mater Protein Homolog; NALP5;
Function
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity).
Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).
Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (By similarity).
Required for cortical actin clearance prior to oocyte exocytosis (By similarity).
Involved in regulating post-fertilization Ca2+ release and endoplasmic reticulum (ER) storage via regulation of ER localization (By similarity).
May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (By similarity).
Biological Process
Actin filament organizationISS:UniProtKB
Cortical granule exocytosisISS:UniProtKB
Establishment of organelle localizationISS:UniProtKB
Establishment of spindle localizationISS:UniProtKB
ExocytosisISS:UniProtKB
Positive regulation of embryonic developmentISS:UniProtKB
Regulation of cell divisionISS:UniProtKB
Regulation of localizationISS:UniProtKB
Cellular Location
Cytoplasmic vesicle, secretory vesicle, Cortical granule
Mitochondrion
Nucleus, nucleolus
Cytoplasm
Golgi apparatus
Involvement in disease
NLRP5 variants have been found in a spectrum of phenotypes characterized by aberrant methylation of multiple imprinted loci, a condition known as multi-locus imprinting defect or multi-locus imprinting disturbance (MLID). MLID-related phenotype spectrum ranges from intrauterine death to different types of imprinting disorders, including Beckwith-Wiedemann syndrome (BWS), Silver-Russell syndrome (SRS), and non-specific developmental and behavioral manifestations. MLID has also been observed in individuals without overt clinical manifestations. Recurrent pregnancy loss has been reported in healthy women carrying NLRP5 variants.
PTM
Phosphorylated by PRKCE.

Huang, X., Sun, Q., Chen, D., Yang, W., Zhang, J., Liu, R., ... & Fu, Q. (2022). Nlrp5 and Tle6 expression patterns in buffalo oocytes and pre‐implantation embryos. Reproduction in Domestic Animals, 57(5), 481-488.

Tong, X., Jin, J., Hu, Z., Zhang, Y., Fan, H. Y., Zhang, Y. L., & Zhang, S. (2022). Mutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest. Human Mutation, 43(12), 1909-1920.

Huang, L., Wang, Y., Lu, F., Jin, Q., Song, G., Ji, J., ... & Tong, X. (2022). Novel mutations in NLRP5 and PATL2 cause female infertility characterized by primarily oocyte maturation abnormality and consequent early embryonic arrest. Journal of Assisted Reproduction and Genetics, 39(3), 711-718.

Li, M., Jia, M., Zhao, X., Shi, R., & Xue, X. (2021). A new NLRP5 mutation causes female infertility and total fertilization failure. Gynecological Endocrinology, 37(3), 283-284.

Rezaei, M., Suresh, B., Bereke, E., Hadipour, Z., Aguinaga, M., Qian, J., ... & Slim, R. (2021). Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure. Clinical Genetics, 99(6), 823-828.

Chen, S., Tao, L., He, X., Di, R., Wang, X., & Chu, M. (2021). Single-nucleotide polymorphisms in FLT3, NLRP5, and TGIF1 are associated with litter size in Small-tailed Han sheep. Archives Animal Breeding, 64(2), 475-486.

Xu, Y., Qian, Y., Liu, Y., Wang, Q., Wang, R., Zhou, Y., ... & Sun, L. (2020). A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family. Clinical Genetics, 98(1), 69-73.

Sparago, A., Verma, A., Patricelli, M. G., Pignata, L., Russo, S., Calzari, L., ... & Riccio, A. (2019). The phenotypic variations of multi-locus imprinting disturbances associated with maternal-effect variants of NLRP5 range from overt imprinting disorder to apparently healthy phenotype. Clinical Epigenetics, 11, 1-10.

Mu, J., Wang, W., Chen, B., Wu, L., Li, B., Mao, X., ... & Wang, L. (2019). Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrest. Journal of Medical Genetics, 56(7), 471-480.

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For research use only. Not intended for any clinical use.

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