Mouse Anti-NLRP9 Recombinant Antibody (CBWJN-0119) (CBMAB-N2710-WJ)

Name: Mouse Anti-NLRP9 Recombinant Antibody (CBWJN-0119)
SKU: CBMAB-N2710-WJ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBWJN-0119

Antibody Isotype

IgM, κ

Application

FC, IHC, WB

Basic Information

Specificity

Human

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NLR Family Pyrin Domain Containing 9

Introduction

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

Entrez Gene ID

338321

UniProt ID

Q7RTR0

Alternative Names

NLR Family Pyrin Domain Containing 9; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 9; Nucleotide-Binding Oligomerization Domain Protein 6; NACHT, Leucine Rich Repeat And PYD Containing 9; PYRIN And NACHT-Containing Protein 12; NALP9;

Function

As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments.

Biological Process

Defense response to virusISS:UniProtKB
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseISS:UniProtKB
Positive regulation of interleukin-18 productionISS:UniProtKB
PyroptosisISS:UniProtKB

Cellular Location

Cytoplasm
Inflammasome

More Infomation

References

Ali, A., Mir, G. J., Ayaz, A., Maqbool, I., Ahmad, S. B., Mushtaq, S., ... & Rehman, M. U. (2023). In silico analysis and molecular docking studies of natural compounds of Withania somnifera against bovine NLRP9. Journal of Molecular Modeling, 29(6), 171.

Qin, G., Yu, X., Zhao, Y., Li, X., Yu, B., Peng, H., & Yang, D. (2023). NLRP9 involved in antiviral innate immunity via binding VIM in IPEC-J2 cells. Developmental & Comparative Immunology, 147, 104895.

Kamitsukasa, Y., Nakano, K., Murakami, K., Hirata, K., Yamamoto, M., Shimizu, T., & Ohto, U. (2022). The structure of NLRP9 reveals a unique C‐terminal region with putative regulatory function. FEBS letters, 596(7), 876-885.

Mullins, B., & Chen, J. (2021). NLRP9 in innate immunity and inflammation. Immunology, 162(3), 262-267.

Zhang, Z., Tang, J., He, X., Di, R., & Chu, M. (2020). Mutations in NLRP5 and NLRP9 are associated with litter size in Small Tail Han sheep. Animals, 10(4), 689.

Ha, H. J., & Park, H. H. (2020). Crystal structure of the human NLRP9 pyrin domain reveals a bent N‐terminal loop that may regulate inflammasome assembly. FEBS letters, 594(15), 2396-2405.

Marleaux, M., Anand, K., Latz, E., & Geyer, M. (2020). Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly. FEBS letters, 594(15), 2383-2395.

de Alba, E. (2020). The mysterious role of the NLRP9 pyrin domain in inflammasome assembly. FEBS letters, 594(15), 2380.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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