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Mouse Anti-NMB Recombinant Antibody (CBWJN-1437) (CBMAB-N2712-WJ)

This product is a Mouse antibody that recognizes NMB. The antibody CBWJN-1437 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all NMB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1437
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuromedin B
Introduction
This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Entrez Gene ID
4828
UniProt ID
P08949
Alternative Names
Neuromedin B; Neuromedin-B-32; Neuromedin-Beta; Neuromedin-B;
Function
Stimulates smooth muscle contraction (By similarity).
Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).
These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).
Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity).
Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity).
Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264).
Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).
Biological Process
Arachidonic acid secretionIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Glucose homeostasisIEA:Ensembl
Negative regulation of hormone secretionIEA:Ensembl
Neuropeptide signaling pathwayIEA:InterPro
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Positive regulation of hormone secretionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Cell projection, neuron projection
In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.

Souza, G. M., Stornetta, D. S., Shi, Y., Lim, E., Berry, F. E., Bayliss, D. A., & Abbott, S. B. (2023). Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice. Journal of Neuroscience, 43(30), 5501-5520.

Li, S., Li, S., Li, Q., Liu, F., Liao, W., Yu, L., ... & Li, M. (2023). Increased Neuromedin B is Associated with a Favorable Prognosis in Glioblastoma. Frontiers in Bioscience-Landmark, 28(3), 54.

Boyle, C. A., & Lei, S. (2023). Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear‐potentiated startle. Journal of Cellular Physiology.

Cikes, D., Atanes, P., Cronin, S. J., Hagelkrüys, A., Huang, G. C., Persaud, S. J., & Penninger, J. M. (2022). Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide. Scientific Reports, 12(1), 9383.

Kiguchi, N., Ding, H., Park, S. H., Mabry, K. M., Kishioka, S., Shiozawa, Y., ... & Ko, M. C. (2022). Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates. Biochemical Pharmacology, 198, 114972.

Ohki-Hamazaki, H. (2021). Neuromedin B. In Handbook of hormones (pp. 337-339). Academic Press.

Park, H. J., Kim, M. K., Kim, Y., Kim, H. J., Bae, S. K., & Bae, M. K. (2021). Neuromedin B modulates phosphate-induced vascular calcification. BMB reports, 54(11), 569.

Maumus, M., Fonteneau, G., Ruiz, M., Assou, S., Boukhaddaoui, H., Pastoureau, P., ... & Noel, D. (2021). Neuromedin B promotes chondrocyte differentiation of mesenchymal stromal cells via calcineurin and calcium signaling. Cell & Bioscience, 11, 1-14.

Chen, J., Shi, Y., Huang, J., Luo, J., & Zhang, W. (2020). Neuromedin B receptor mediates neuromedin B-induced COX-2 and IL-6 expression in human primary myometrial cells. Journal of Investigative Medicine, 68(6), 1171-1178.

Yang, G., Huang, H., Tang, M., Cai, Z., Huang, C., Qi, B., & Chen, J. L. (2019). Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo. Veterinary research, 50(1), 80.

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For research use only. Not intended for any clinical use.

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