NMB

This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Full Name

Neuromedin B

Function

Stimulates smooth muscle contraction (By similarity).
Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity).
These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity).
Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity).
Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity).
Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264).
Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).

Biological Process

Arachidonic acid secretionIEA:Ensembl
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Glucose homeostasisIEA:Ensembl
Negative regulation of hormone secretionIEA:Ensembl
Neuropeptide signaling pathwayIEA:InterPro
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Positive regulation of hormone secretionManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted
Cell projection, neuron projection
In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.