Mouse Anti-NMRAL1 Recombinant Antibody (CBFYH-2674) (CBMAB-H3726-FY)

This product is mouse antibody that recognizes NMRAL1. The antibody CBFYH-2674 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NMRAL1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYH-2674

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NmrA-like family domain containing 1

Introduction

This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants.

Entrez Gene ID

57407

UniProt ID

Q9HBL8

Alternative Names

NmrA Like Redox Sensor 1; Short Chain Dehydrogenase/Reductase Family 48A, Member 1; NmrA-Like Family Domain Containing 1; HSCARG; NmrA-Like Family Domain-Containing Protein 1; SDR48A1

Function

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP+ ratios.

References

Wang, J., Li, S., Li, X., Liu, J., Yang, J., Li, Y., ... & Luo, X. J. (2022). Functional variant rs2270363 on 16p13. 3 confers schizophrenia risk by regulating NMRAL1. Brain, 145(7), 2569-2585.

Gao, Z., Ti, Y., Lu, B., Song, F. Q., Zhang, L., Hu, B. A., ... & Zhong, M. (2022). STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3219-3229.

Yan, Y., Wang, G. W., Kong, F. D., Wang, X. Y., Wang, Y. H., Li, J. P., ... & Jiang, L. (2022). Mechanism of NMRAL1 regulating influenza virus replication.

Zang, W., & Zheng, X. (2020). Structure and functions of cellular redox sensor HSCARG/NMRAL1, a linkage among redox status, innate immunity, DNA damage response, and cancer. Free Radical Biology and Medicine, 160, 768-774.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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