Mouse Anti-NMRK2 Recombinant Antibody (CBFYM-3032) (CBMAB-M3228-FY)

This product is mouse antibody that recognizes NMRK2. The antibody CBFYM-3032 can be used for immunoassay techniques such as: WB.
See all NMRK2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-3032

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Recombinant human MIBP

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 50% glycerol

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NICOTINAMIDE RIBOSIDE KINASE 2

Introduction

Catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside to form nicotinamide mononucleotide and nicotinic acid mononucleotide. Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.

Entrez Gene ID

27231

UniProt ID

Q9NPI5

Alternative Names

Nicotinamide Riboside Kinase 2; Muscle-Specific Beta 1 Integrin Binding Protein; Integrin Beta-1-Binding Protein 3; Nicotinic Acid Riboside Kinase 2; Ribosylnicotinic Acid Kinase 2; Ribosylnicotinamide Kinase 2; ITGB1BP3; NmR-K 2; NRK 2

Function

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.

Biological Process

NAD biosynthetic processIEA:UniProtKB-UniPathway
NAD metabolic processTAS:Reactome
Negative regulation of myoblast differentiationIEA:Ensembl

Cellular Location

cytoplasm
cytosol
intracellular membrane-bounded organelle
nucleoplasm
plasma membrane

References

Chen, Y., Lu, Y., Yang, L., Ma, W., Dong, Y., Zhou, S., ... & Li, D. (2023). LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner. Journal of Experimental & Clinical Cancer Research, 42(1), 252.

Chen, Y., Yang, L., Lu, Y., Liu, N., Ma, W., Fan, H., ... & Li, D. (2022). Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11. 2 translocation renal cell carcinoma. Cancer Letters, 538, 215689.

Minor, K., Gu, H., Lee, C. F., & Light, C. (2022). Abstract P3039: NAD Redox Imbalance Exacerbates Diabetic Cardiomyopathy, Regulates Nmrk2 Expression And Alters NAD Synthesis. Circulation Research, 131(Suppl_1), AP3039-AP3039.

Tannous, C., Deloux, R., Karoui, A., Mougenot, N., Burkin, D., Blanc, J., ... & Mericskay, M. (2021). NMRK2 gene is upregulated in dilated cardiomyopathy and required for cardiac function and NAD levels during aging. International Journal of Molecular Sciences, 22(7), 3534.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-NMRK2 Recombinant Antibody (CBFYM-3032)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: