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Mouse Anti-NOMO1 Recombinant Antibody (9E6) (CBMAB-N2912-WJ)

This product is a Mouse antibody that recognizes NOMO1. The antibody 9E6 can be used for immunoassay techniques such as: WB.
See all NOMO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9E6
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 2% sucrose
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nodal modulator 1
Introduction
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]
Entrez Gene ID
23420
UniProt ID
Q15155
Alternative Names
NODAL Modulator 1; PM5; PM5 Protein, Telomeric Copy; Nodal Modulator 3; PM5 Protein 3; PM5 Protein; Nomo;
Function
Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719).
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity).
Cellular Location
Endoplasmic reticulum membrane
Topology
Extracellular: 32-1155
Helical: 1156-1176
Cytoplasmic: 1177-1222

Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., ... & Li, Q. (2024). Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports, 25(2), 570-592.

Pérez-García, J., Martel-Martel, A., García-Vallés, P., Corchete, L. A., García, J. L., Gestoso-Uzal, N., ... & González-Sarmiento, R. (2022). Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration. Cancers, 14(16), 4029.

Pérez-García, J., Martel Martel, A. J., García-Vallés, P., Corchete, L. A., García, J. L., Gestoso-Uzal, N., ... & González-Sarmiento, R. (2022). Supplementary materials of the article Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration [Dataset].

Xing, W., Li, T., Wang, Y., Qiang, Y., Ai, C., & Tang, H. (2021). MiR-33a-5p targets NOMO1 to modulate human cardiomyocyte progenitor cells proliferation and differentiation and apoptosis. Journal of Receptors and Signal Transduction, 41(5), 476-487.

Li, F., Li, T., Lin, J., Jian, J., Zhang, Q., Zhang, Y., ... & Li, Q. (2021). Morphological, behavioral and molecular studies on CRISPR/Cas9-mediated knockout of the NOMO1 gene in zebrafish.

Zhao, T., Hu, Y., Zang, T., & Cheng, L. (2020). MRTFB regulates the expression of NOMO1 in colon. Proceedings of the National Academy of Sciences, 117(14), 7568-7569.

García-Tuñón, I., Vuelta, E., Lozano, L., Herrero, M., Méndez, L., Palomero-Hernandez, J., ... & Sánchez-Martín, M. (2020). Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology. Molecular Biology Reports, 47, 1381-1391.

Marian, T. A., & Wei, Z. (2020). Reply to Zhao et al.: NOMO1 is a potential target gene of MRTFB. Proceedings of the National Academy of Sciences, 117(14), 7570-7571.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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