Mouse Anti-NOMO1 Recombinant Antibody (9E6) (CBMAB-N2912-WJ)

Name: Mouse Anti-NOMO1 Recombinant Antibody (9E6)
SKU: CBMAB-N2912-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

9E6

Application

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 2% sucrose

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nodal modulator 1

Introduction

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]

Entrez Gene ID

23420

UniProt ID

Q15155

Alternative Names

NODAL Modulator 1; PM5; PM5 Protein, Telomeric Copy; Nodal Modulator 3; PM5 Protein 3; PM5 Protein; Nomo;

Function

Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719).
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN/Nicalin (By similarity).

Cellular Location

Endoplasmic reticulum membrane

Topology

Extracellular: 32-1155
Helical: 1156-1176
Cytoplasmic: 1177-1222

Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., ... & Li, Q. (2024). Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports, 25(2), 570-592.

Pérez-García, J., Martel-Martel, A., García-Vallés, P., Corchete, L. A., García, J. L., Gestoso-Uzal, N., ... & González-Sarmiento, R. (2022). Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration. Cancers, 14(16), 4029.

Pérez-García, J., Martel Martel, A. J., García-Vallés, P., Corchete, L. A., García, J. L., Gestoso-Uzal, N., ... & González-Sarmiento, R. (2022). Supplementary materials of the article Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration [Dataset].

Xing, W., Li, T., Wang, Y., Qiang, Y., Ai, C., & Tang, H. (2021). MiR-33a-5p targets NOMO1 to modulate human cardiomyocyte progenitor cells proliferation and differentiation and apoptosis. Journal of Receptors and Signal Transduction, 41(5), 476-487.

Li, F., Li, T., Lin, J., Jian, J., Zhang, Q., Zhang, Y., ... & Li, Q. (2021). Morphological, behavioral and molecular studies on CRISPR/Cas9-mediated knockout of the NOMO1 gene in zebrafish.

Zhao, T., Hu, Y., Zang, T., & Cheng, L. (2020). MRTFB regulates the expression of NOMO1 in colon. Proceedings of the National Academy of Sciences, 117(14), 7568-7569.

García-Tuñón, I., Vuelta, E., Lozano, L., Herrero, M., Méndez, L., Palomero-Hernandez, J., ... & Sánchez-Martín, M. (2020). Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology. Molecular Biology Reports, 47, 1381-1391.

Marian, T. A., & Wei, Z. (2020). Reply to Zhao et al.: NOMO1 is a potential target gene of MRTFB. Proceedings of the National Academy of Sciences, 117(14), 7570-7571.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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